Supramolecular Photothermal Nanomaterials as an Emerging Paradigm toward Precision Cancer Therapy | |
Zhao, Luyang1; Liu, Yamei1; Chang, Rui1,2; Xing, Ruirui1; Yan, Xuehai1,2,3 | |
刊名 | ADVANCED FUNCTIONAL MATERIALS |
2019-01-24 | |
卷号 | 29期号:4页码:12 |
关键词 | Intermolecular Interaction Photosensitizer Photothermal Therapy Self-assembly Supramolecular Photothermal Effect |
ISSN号 | 1616-301X |
DOI | 10.1002/adfm.201806877 |
英文摘要 | The concept of the "supramolecular photothermal effects" refers to the collection property and photothermal conversion efficiency resulting from the supramolecular assembly of molecular photothermal sensitizers. This review considers organic supramolecular photothermal materials assembled at the nanoscale via various molecular self-assembly strategies and associated with the organization of multiple noncovalent interactions. In these materials, the individual photosensitizer molecules are typically aggregated through self-assembly in a certain form that exhibits enhanced biostability, increased photothermal conversion efficiency with photoluminescence quenching, and improved photothermal therapeutic effects in comparison with those of the monomeric photosensitizer molecules. These supramolecular photothermal effects are controlled or influenced by intermolecular noncovalent interactions, especially the hydrophobic effects, which are distinct from the mechanisms of conventional sensitizer molecules and polymers and inorganic photothermal agents. A focus lies on how self-assembly strategies give rise to supramolecular photothermal effects, including polymer and protein fabrication, small molecule self-assembly, and the construction of donor-acceptor binary systems. Emphases are placed on the rational design of supramolecular photothermal nanomaterials, drug delivery, and in vivo photothermal therapeutic effects. Finally, the key challenges and promising prospects of these supramolecular photothermal nanomaterials in terms of both technical advances and clinical translation are discussed. |
资助项目 | National Natural Science Foundation of China[21522307] ; National Natural Science Foundation of China[21703252] ; National Natural Science Foundation of China[21473208] ; National Natural Sciences Fund BRICS STI Framework Programme[51861145304] ; China Postdoctoral Science Foundation[2017M610113] ; Talent Fund of the Recruitment Program of Global Youth Experts ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034] ; CAS President's International Fellowship Initiative[2018VEA0005] |
WOS关键词 | Efficient Photodynamic Therapy ; Near-infrared Dye ; Drug-delivery ; Polymeric Nanoparticles ; Ferritin Nanocages ; Co-delivery ; In-vitro ; Tumor ; Photosensitizers ; Albumin |
WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
语种 | 英语 |
出版者 | WILEY-V C H VERLAG GMBH |
WOS记录号 | WOS:000456216900007 |
资助机构 | National Natural Science Foundation of China ; National Natural Sciences Fund BRICS STI Framework Programme ; China Postdoctoral Science Foundation ; Talent Fund of the Recruitment Program of Global Youth Experts ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS) ; CAS President's International Fellowship Initiative |
内容类型 | 期刊论文 |
源URL | [http://ir.ipe.ac.cn/handle/122111/27788] |
专题 | 中国科学院过程工程研究所 |
通讯作者 | Yan, Xuehai |
作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 North Second St, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, 1 North Second St, Beijing 100190, Peoples R China |
推荐引用方式 GB/T 7714 | Zhao, Luyang,Liu, Yamei,Chang, Rui,et al. Supramolecular Photothermal Nanomaterials as an Emerging Paradigm toward Precision Cancer Therapy[J]. ADVANCED FUNCTIONAL MATERIALS,2019,29(4):12. |
APA | Zhao, Luyang,Liu, Yamei,Chang, Rui,Xing, Ruirui,&Yan, Xuehai.(2019).Supramolecular Photothermal Nanomaterials as an Emerging Paradigm toward Precision Cancer Therapy.ADVANCED FUNCTIONAL MATERIALS,29(4),12. |
MLA | Zhao, Luyang,et al."Supramolecular Photothermal Nanomaterials as an Emerging Paradigm toward Precision Cancer Therapy".ADVANCED FUNCTIONAL MATERIALS 29.4(2019):12. |
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