Synthesis, characterization, and antimicrobial activity of novel hydrazone-bearing tricyclic quinazolines | |
Nasrullaev, A (Nasrullaev, Azizbek)[ 1,2 ]; Bozorov, K (Bozorov, Khurshed)[ 1,2 ]; Bobakulov, K (Bobakulov, Khayrulla)[ 1,2 ]; Zhao, JY (Zhao, Jiangyu)[ 1 ]; Nie, LF (Nie, Li Fei)[ 1 ]; Turgunov, KK (Turgunov, Kambarali K.)[ 2 ]; Elmuradov, B (Elmuradov, Burkhon)[ 2 ]; Aisa, HA (Aisa, Haji A.)[ 1 ] | |
刊名 | RESEARCH ON CHEMICAL INTERMEDIATES |
2019 | |
卷号 | 45期号:4页码:2287-2300 |
关键词 | Quinazoline Quinazoline-thione Hydrazone Thioamide Antimicrobial activity |
ISSN号 | 0922-6168 |
DOI | 10.1007/s11164-018-03731-x |
英文摘要 | A series of novel substituted hydrazone-bearing (unsymmetrical azines, RR1C=N-N=CR2R3) tricyclic quinazoline derivatives are reported. All novel compounds were characterized by H-1, C-13 nuclear magnetic resonance (NMR), and Fourier-transform infrared (FT-IR) analyses. An important intermediate (E/Z)-hydrazono-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazoline (8) was synthesized from tricyclic quinazoline-4-thione 7 using 80% of hydrazine hydrate. In addition, the antimicrobial activity of all synthesized novel compounds against three types of pathogenic microorganism was tested, revealing that some compounds showed satisfactory good activity and could serve as lead compounds for further drug discovery and development. |
WOS记录号 | WOS:000461305200032 |
内容类型 | 期刊论文 |
源URL | [http://ir.xjipc.cas.cn/handle/365002/5705] |
专题 | 新疆理化技术研究所_省部共建新疆特有药用资源利用重点实验室 新疆理化技术研究所_资源化学研究室 |
通讯作者 | Aisa, HA (Aisa, Haji A.)[ 1 ] |
作者单位 | 1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Reg, 40-1 South Beijing Rd, Urumqi 830011, Peoples R China 2.Acad Sci Uzbek, Inst Chem Plant Subst, Mirzo Ulugbek Str 77, Tashkent 100170, Uzbekistan |
推荐引用方式 GB/T 7714 | Nasrullaev, A ,Bozorov, K ,Bobakulov, K ,et al. Synthesis, characterization, and antimicrobial activity of novel hydrazone-bearing tricyclic quinazolines[J]. RESEARCH ON CHEMICAL INTERMEDIATES,2019,45(4):2287-2300. |
APA | Nasrullaev, A .,Bozorov, K .,Bobakulov, K .,Zhao, JY .,Nie, LF .,...&Aisa, HA .(2019).Synthesis, characterization, and antimicrobial activity of novel hydrazone-bearing tricyclic quinazolines.RESEARCH ON CHEMICAL INTERMEDIATES,45(4),2287-2300. |
MLA | Nasrullaev, A ,et al."Synthesis, characterization, and antimicrobial activity of novel hydrazone-bearing tricyclic quinazolines".RESEARCH ON CHEMICAL INTERMEDIATES 45.4(2019):2287-2300. |
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