Advances in the mechanism of mechanochemical coupling of kinesin

doi:http://dx.doi.org/10.7498/aps.65.188702

CORC > 理论物理研究所 > 中国科学院理论物理研究所 > 理论物理所科研产出 > 理论物理所1978-2010年知识产出

	Advances in the mechanism of mechanochemical coupling of kinesin
	Li, M; Ouyang, ZC; Shu, YG
刊名	ACTA PHYSICA SINICA
	2016
卷号	65 期号:18 页码:188702
关键词	kinesin BOVINE BRAIN KINESIN single molecule technology SQUID GIANT-AXON mechanochemical coupling HAND-OVER-HAND NECK LINKER 8-NM STEP MOLECULAR MOTORS FORCE MICROSCOPY MOVEMENT MOTILITY
DOI	http://dx.doi.org/10.7498/aps.65.188702
英文摘要	Kinesin is one of the most important linear motors for intracellular transport. It has two main features. One is its persistence: at least one head is attached to the microtubule during stepping, so that it can move a long distance before detaching. Another feature is the tight mechanochemical coupling: it consumes one adenosine-triphosphate for each step. Therefore, there should be a mechanism responsible for the coordination of the two heads to achieve the high persistence and tight coupling. The underlying mechanism is the mechanochemical coupling, which is the basic issue for all chemical-driven molecular motors. Owing to the developments of single-molecule experiments and molecular dynamics simulations, a breakthrough in the coupling mechanism has been made in recent decades. In this article, we review the progress of the relevant researches from the perspective of kinematics, energetics, coordination of two heads and force generating mechanism. We also present a personal perspective on the future studies of kinesin.
学科主题	Physics
语种	中文
资助机构	National Basic Research Program of China [2013CB932804] ; National Natural Science Foundation of China [11574329, 11322543, 11105218] ; Joint NSFC-ISF Research Program [51561145002]
内容类型	期刊论文
源URL	[http://ir.itp.ac.cn/handle/311006/23031]
专题	理论物理研究所_理论物理所1978-2010年知识产出
作者单位	1.Univ Chinese Acad Sci, Sch Phys Sci, Beijing 100049, Peoples R China 2.[Li Ming 3.Chinese Acad Sci, Inst Theoret Phys, Beijing 100190, Peoples R China 4.[Ouyang Zhong-Can
推荐引用方式 GB/T 7714	Li, M,Ouyang, ZC,Shu, YG. Advances in the mechanism of mechanochemical coupling of kinesin[J]. ACTA PHYSICA SINICA,2016,65(18):188702.
APA	Li, M,Ouyang, ZC,&Shu, YG.(2016).Advances in the mechanism of mechanochemical coupling of kinesin.ACTA PHYSICA SINICA,65(18),188702.
MLA	Li, M,et al."Advances in the mechanism of mechanochemical coupling of kinesin".ACTA PHYSICA SINICA 65.18(2016):188702.