A human gut phage catalog correlates the gut phageome with type 2 diabetes.

	A human gut phage catalog correlates the gut phageome with type 2 diabetes.
	Tokuyasu, Taku; Ma, Yingfei; You, Xiaoyan; Mai, Guoqin; Liu, Chenli
刊名	MICROBIOME
	2018
文献子类	期刊论文
英文摘要	Background: Substantial efforts have been made to link the gut bacterial community to many complex human diseases. Nevertheless, the gut phages are often neglected. Results: In this study, we used multiple bioinformatic methods to catalog gut phages from whole-community metagenomic sequencing data of fecal samples collected from both type II diabetes (T2D) patients (n = 71) and normal Chinese adults (n = 74). The definition of phage operational taxonomic units (pOTUs) and identification of large phage scaffolds (n = 2567, = 10 k) revealed a comprehensive human gut phageome with a substantial number of novel sequences encoding genes that were unrelated to those in known phages. Interestingly, we observed a significant increase in the number of gut phages in the T2D group and, in particular, identified 7 pOTUs specific to T2D. This finding was further validated in an independent dataset of 116 T2D and 109 control samples. Co-occurrence/exclusion analysis of the bacterial genera and pOTUs identified a complex core interaction between bacteria and phages in the human gut ecosystem, suggesting that the significant alterations of the gut phageome cannot be explained simply by co-variation with the altered bacterial hosts. Conclusions: Alterations in the gut bacterial community have been linked to the chronic disease T2D, but the role of gut phages therein is not well understood. This is the first study to identify a T2D-specific gut phageome, indicating the existence of other mechanisms that might govern the gut phageome in T2D patients. These findings suggest the importance of the phageome in T2D risk, which warrants further investigation.
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/13417]
专题	合成所
推荐引用方式 GB/T 7714	Tokuyasu, Taku,Ma, Yingfei,You, Xiaoyan,et al. A human gut phage catalog correlates the gut phageome with type 2 diabetes.[J]. MICROBIOME,2018.
APA	Tokuyasu, Taku,Ma, Yingfei,You, Xiaoyan,Mai, Guoqin,&Liu, Chenli.(2018).A human gut phage catalog correlates the gut phageome with type 2 diabetes..MICROBIOME.
MLA	Tokuyasu, Taku,et al."A human gut phage catalog correlates the gut phageome with type 2 diabetes.".MICROBIOME (2018).