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	Placental chondroitin sulfate A (plCSA)-binding peptide (plCSA-BP) as a tool for targeted delivery of payloads to the placenta and human cancer
	Lintao Cai; Baozhen Zhang; Mingbin Zheng; Guogang Cheng; Jinyu Han; Zhilong Chen; Xiujun Fan
	2018
会议日期	2018
会议地点	上海
英文摘要	Placenta shares similar characteristics with cancer, including fast proliferation, invasive and immune tolerance. Hence researchers have attempted to identify molecules shared between the placental and malignant compartments for decades. Placental chondroitin sulfate A (plCSA) has been found recently as a biomarker that exclusively expressed on the placental trophoblast and most the human cancer cells. We have developed a method for targeted delivery of payloads to the placenta and human cancers using a synthetic plCSA-binding peptide (plCSA-BP) derived from malarial protein, VAR2CSA, that mediates the binding of infected erythrocytes (IEs) to plCSA present on placental syncytiotrophoblasts. We show that intravenously administered plCSA-BP-conjugated nanoparticles loaded with indocyanine green (plCSA-INPs) rapidly and efficiently bonded to placental trophoblasts and cancer cells. In tumor model, plCSA-BP-conjugated nanoparticles loaded with doxorubicin (plCSA-DNPs) strongly inhibited choriocarcinoma (JEG3 cells), prostate cancer (PC3 cells), lung cancer (A549 cells) xenotumor grafts growth and, more importantly, significantly suppressed metastasis in vivo. In pregnant mice, plCSA-BP-guided nanoparticles could efficiently targeted delivery of payloads to the placenta. Importantly, these nanoparticles had no apparent adverse effects on maternal and fetal tissues. These results demonstrate that plCSA-BP could serve as a novel tool for targeted delivery of payloads to the placenta and human cancer.
语种	英语
内容类型	会议论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/14760]
专题	深圳先进技术研究院_医药所
推荐引用方式 GB/T 7714	Lintao Cai,Baozhen Zhang,Mingbin Zheng,et al. Placental chondroitin sulfate A (plCSA)-binding peptide (plCSA-BP) as a tool for targeted delivery of payloads to the placenta and human cancer[C]. 见:. 上海. 2018.

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