Theranostic nanoagent for photoacoustic/magnetic resonance dual-modal imaging-guided cancer photothermal therapy

	Theranostic nanoagent for photoacoustic/magnetic resonance dual-modal imaging-guided cancer photothermal therapy
	Dehong Hu; Chengbo Liu; Zonghai Sheng; Lintao Cai; Hairong Zheng
刊名	Nanomedicine: Nanotechnology, Biology and Medicine
	2018
文献子类	会议论文
英文摘要	Cancer has been becoming one of major threats to human health.1Development of highly integrated strategies for precise diagnosis and efficient therapy of cancer has attracted much attention in the past decades. Imaging-guided therapy as a novel theranostic strategy demonstrates an enhancement in location of tumor site, detection of treatment process and evaluation of therapeutic efficiency. The design and preparation of theranostic nanoagents that integrate imaging and therapy functionalities into a single nanoplatform hold a great promise to enhance the accuracy of diagnosis and improve the efficacy of therapy.Herein, we develop a theranostic nanoagent based on indocyanine green(ICG)-loaded polydopamine (PDA)-iron ions coordination nanoparticles(PDA-Fe3+-ICG NPs), which is used for photoacoustic (PA) and magnetic resonance (MR) dual-modal imaging-guided cancer PTT treatments. In this nanoplatform, ICG molecules, the U.S. Food and Drug Administration approved near-infrared (NIR) dye, absorb PDA NPs (a melanin-like biopolymer) to significantly increase the NIR optical absorption of PDA NPs nearly 6 times and decrease their fluorescence emission, which could improve PA contrast ability and promote photothermal conversion efficiency of PDA NPs. Meanwhile,Fe3+ ions chelated on PDA NPs offer T1-weighted MRI contrast agent (r1=14 mM−1s−1). In mouse 4T1 breast tumor model, the PA/MRI dual-modal imaging and highly efficient PTT treatments with low laser density are achieved with remarkable therapeutic efficiency and minimal side effects. This study illustrates that the highly integrated and biocompatible PDA-based NPs could serve as a versatile nanoplatform with loading different imaging molecules and drugs for multi-modal imaging and cancer combination therapy.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/14628]
专题	深圳先进技术研究院_医药所
推荐引用方式 GB/T 7714	Dehong Hu,Chengbo Liu,Zonghai Sheng,et al. Theranostic nanoagent for photoacoustic/magnetic resonance dual-modal imaging-guided cancer photothermal therapy[J]. Nanomedicine: Nanotechnology, Biology and Medicine,2018.
APA	Dehong Hu,Chengbo Liu,Zonghai Sheng,Lintao Cai,&Hairong Zheng.(2018).Theranostic nanoagent for photoacoustic/magnetic resonance dual-modal imaging-guided cancer photothermal therapy.Nanomedicine: Nanotechnology, Biology and Medicine.
MLA	Dehong Hu,et al."Theranostic nanoagent for photoacoustic/magnetic resonance dual-modal imaging-guided cancer photothermal therapy".Nanomedicine: Nanotechnology, Biology and Medicine (2018).