Novel Pyrrole−Imidazole Polyamide Hoechst Conjugate Suppresses Epstein−Barr Virus Replication and Virus-Positive Tumor Growth

	Novel Pyrrole−Imidazole Polyamide Hoechst Conjugate Suppresses Epstein−Barr Virus Replication and Virus-Positive Tumor Growth
	Zhehong Cheng; Wei Wang; Chunlei Wu; Xiaohua Zou; Lijing Fang; Wu Su; Pu Wang
刊名	JOURNAL OF MEDICINAL CHEMISTRY
	2018
文献子类	期刊论文
英文摘要	Epstein−Barr virus (EBV) establishes latent infection and is associated with several types of lymphomas and carcinomas. EBV nuclear antigen 1 (EBNA1) is expressed in all EBV-positive tumor cells. EBNA1 binds to the origin of virus plasmid replication (OriP) on the EBV episome to initiate virus DNA replication and regulates virus gene expression as a transcriptional activator. In this study, we designed and synthesized a pyrrole−imidazole polyamide−Hoechst 33258 conjugate named EIP-2 (2), which specifically binds to the OriP region with high affinity, to interrupt EBNA1-OriP binding in vitro and in vivo. By eradicating the EBV episome in EBV-positive cells, compound 2 selectively inhibited EBV-positive cell proliferation. Moreover, the injection of 2 significantly suppressed tumor growth in the mice xenograft tumor model. These findings demonstrate that compound 2 is a potential therapeutic candidate for the treatment of EBV-associated tumors
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/14618]
专题	深圳先进技术研究院_医药所
推荐引用方式 GB/T 7714	Zhehong Cheng,Wei Wang,Chunlei Wu,et al. Novel Pyrrole−Imidazole Polyamide Hoechst Conjugate Suppresses Epstein−Barr Virus Replication and Virus-Positive Tumor Growth[J]. JOURNAL OF MEDICINAL CHEMISTRY,2018.
APA	Zhehong Cheng.,Wei Wang.,Chunlei Wu.,Xiaohua Zou.,Lijing Fang.,...&Pu Wang.(2018).Novel Pyrrole−Imidazole Polyamide Hoechst Conjugate Suppresses Epstein−Barr Virus Replication and Virus-Positive Tumor Growth.JOURNAL OF MEDICINAL CHEMISTRY.
MLA	Zhehong Cheng,et al."Novel Pyrrole−Imidazole Polyamide Hoechst Conjugate Suppresses Epstein−Barr Virus Replication and Virus-Positive Tumor Growth".JOURNAL OF MEDICINAL CHEMISTRY (2018).