Dye-Anchored MnO Nanoparticles Targeting Tumor and Inducing Enhanced Phototherapy Effect via Mitochondria-Mediated Pathway

	Dye-Anchored MnO Nanoparticles Targeting Tumor and Inducing Enhanced Phototherapy Effect via Mitochondria-Mediated Pathway
	Zhou, Lihua; Wu, Yayun; Meng, Xiaoqing; Li, Sanpeng; Zhang, Jiali; Gong, Ping; Zhang, Pengfei; Jiang, Tao; Deng, Guanjun; Li, Wenjun
刊名	SMALL
	2018
文献子类	期刊论文
英文摘要	Phototherapy is a promising treatment method for cancer therapy. However, the various factors have greatly restricted phototherapy development, including the poor accumulation of photosensitizer in tumor, hypoxia in solid tumor tissue and systemic phototoxicity. Herein, a mitochondrial-targeted multifunctional dye-anchored manganese oxide nanoparticle (IR808@MnO NP) is developed for enhancing phototherapy of cancer. In this nanoplatform, IR808 as a small molecule dye acts as a tumor targeting ligand to make IR808@MnO NPs with capacity to actively target tumor cells and relocate finally in the mitochondria. Meanwhile, continuous production of oxygen (O-2) and regulation of pH induced by the high reactivity and specificity of MnO NPs toward mitochondrial endogenous hydrogen peroxide (H2O2) could effectively modulate tumor hypoxia and lessen the tumor subacid environment. Large amounts of reactive oxide species (ROS) are generated during the reaction process between H2O2 and MnO NPs. Furthermore, under laser irradiation, IR808 in IR808@MnO NPs turns O-2 into a highly toxic singlet oxygen (O-1(2)) and generates hyperthermia. The results indicate that IR808@MnO NPs have the high efficiency of specific targeting of tumors, relieving tumor subacid environment, improving the tumor hypoxia environment, and generating large amounts of ROS to kill tumor cells. It is expected to have a wide application in treating cancer.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/14613]
专题	深圳先进技术研究院_医药所
推荐引用方式 GB/T 7714	Zhou, Lihua,Wu, Yayun,Meng, Xiaoqing,et al. Dye-Anchored MnO Nanoparticles Targeting Tumor and Inducing Enhanced Phototherapy Effect via Mitochondria-Mediated Pathway[J]. SMALL,2018.
APA	Zhou, Lihua.,Wu, Yayun.,Meng, Xiaoqing.,Li, Sanpeng.,Zhang, Jiali.,...&Cai, Lintao.(2018).Dye-Anchored MnO Nanoparticles Targeting Tumor and Inducing Enhanced Phototherapy Effect via Mitochondria-Mediated Pathway.SMALL.
MLA	Zhou, Lihua,et al."Dye-Anchored MnO Nanoparticles Targeting Tumor and Inducing Enhanced Phototherapy Effect via Mitochondria-Mediated Pathway".SMALL (2018).