Bioinspired Hybrid Protein Oxygen Nanocarrier Amplified Photodynamic Therapy for Eliciting Anti-tumor Immunity and Abscopal Effect

	Bioinspired Hybrid Protein Oxygen Nanocarrier Amplified Photodynamic Therapy for Eliciting Anti-tumor Immunity and Abscopal Effect
	Ruijing Liang; Lanlan Liu; Zhikuan Chen; Zhenyu Luo; Huamei He; Zhihao Wu; Hao Tian; Mingbin Zheng; Yifan Ma; Lintao Cai
刊名	ACS Nano
	2018
文献子类	期刊论文
英文摘要	Near-infrared (NIR) fluorescence imaging has relied on fluorophores that emit in the 700-900 nm An ideal cancer therapeutic strategy is expected to possess potent ability to not only ablate primary tumors but also prevent distance metastasis and relapse. In this study, human serum albumin was hybridized with hemoglobin by intermolecular disulfide bonds to develop a hybrid protein oxygen nanocarrier with chlorine e6 encapsulated (C@HPOC) for oxygen selfsufficient photodynamic therapy (PDT). C@HPOC realized the tumor-targeted co-delivery of photosensitizer and oxygen, which remarkably relieved tumor hypoxia. C@HPOC was favorable for more efficient PDT and enhanced infiltration of CD8+ T cells in tumors. Moreover, oxygen-boosted PDT of C@HPOC induced immunogenic cell death, with the release of danger-associated molecular patterns to activate dendritic cells, T lymphocytes, and natural killer cells in vivo. Notably, C@HPOC-mediated immunogenic PDT could destroy primary tumors and effectively suppress distant tumors and lung metastasis in a metastatic triple-negative breast cancer model by evoking systemic anti-tumor immunity. This study provides a paradigm of oxygenaugmented immunogenic PDT for metastatic cancer treatment.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/14607]
专题	深圳先进技术研究院_医药所
推荐引用方式 GB/T 7714	Ruijing Liang,Lanlan Liu,Zhikuan Chen,et al. Bioinspired Hybrid Protein Oxygen Nanocarrier Amplified Photodynamic Therapy for Eliciting Anti-tumor Immunity and Abscopal Effect[J]. ACS Nano,2018.
APA	Ruijing Liang.,Lanlan Liu.,Zhikuan Chen.,Zhenyu Luo.,Huamei He.,...&Lintao Cai.(2018).Bioinspired Hybrid Protein Oxygen Nanocarrier Amplified Photodynamic Therapy for Eliciting Anti-tumor Immunity and Abscopal Effect.ACS Nano.
MLA	Ruijing Liang,et al."Bioinspired Hybrid Protein Oxygen Nanocarrier Amplified Photodynamic Therapy for Eliciting Anti-tumor Immunity and Abscopal Effect".ACS Nano (2018).