Construction of bionic tissue engineering cartilage scaffold based on three-dimensional printing and oriented frozen technology.

	Construction of bionic tissue engineering cartilage scaffold based on three-dimensional printing and oriented frozen technology.
	Guo, Xiao; Li, Long; Zhang, Peng; Liu, Changyong; Mi, Shengli; Sun, Wei; Xu, Yuanyuan; Yang, Shuaitao
刊名	JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
	2018
文献子类	期刊论文
英文摘要	Articular cartilage (AC) has gradient features in both mechanics and histology as well as a poor regeneration ability. The repair of AC poses difficulties in both research and the clinic. In this paper, a gradient scaffold based on poly(lactic-co-glycolic acid) (PLGA)-extracellular matrix was proposed. Cartilage scaffolds with a three-layer gradient structure were fabricated by PLGA through three-dimensional printing, and the microstructure orientation and pore fabrication were made by decellularized extracellular matrix injection and directional freezing. The manufactured scaffold has a mechanical strength close to that of real cartilage. A quantitative optimization of the Young's modulus and shear modulus was achieved by material mechanics formulas, which achieved a more accurate mechanical bionic and a more stable interface performance because of the one-time molding process. At the same time, the scaffolds have a bionicand gradient microstructure orientation and pore size, and the stratification ratio can be quantitatively optimized by design of the freeze box and temperature simulation. In general, this paper provides a method to optimize AC scaffolds by both mechanics and histology as well as a bionic multimaterial scaffold. This paper is of significance for cell culture and clinical transplantation experiments.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/14423]
专题	深圳先进技术研究院_医工所
推荐引用方式 GB/T 7714	Guo, Xiao,Li, Long,Zhang, Peng,et al. Construction of bionic tissue engineering cartilage scaffold based on three-dimensional printing and oriented frozen technology.[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2018.
APA	Guo, Xiao.,Li, Long.,Zhang, Peng.,Liu, Changyong.,Mi, Shengli.,...&Yang, Shuaitao.(2018).Construction of bionic tissue engineering cartilage scaffold based on three-dimensional printing and oriented frozen technology..JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A.
MLA	Guo, Xiao,et al."Construction of bionic tissue engineering cartilage scaffold based on three-dimensional printing and oriented frozen technology.".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2018).