Imaging-Guided Dual-Target Neuromodulation of the Mouse Brain Using Array Ultrasound

	Imaging-Guided Dual-Target Neuromodulation of the Mouse Brain Using Array Ultrasound
	Wang, Congzhi; Li, Guofeng; Qiu, Weibao; Hong, Jiehan; Jiang, Qiuju; Su, Min; Mu, Peitian; Yang, Ge; Li, Yongchuan; Zhang, Huailing
刊名	IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
	2018
文献子类	期刊论文
英文摘要	Neuromodulation is an important method for investigating neural circuits and treating neurological and psychiatric disorders. Multiple-target neuromodulation is considered an advanced technology for the flexible optimization of modulation effects. However, traditional methods such as electrical and magnetic stimulations are not convenient for multiple-target applications due to their disadvantages of invasiveness or poor spatial resolution. Ultrasonic neuromodulation is a new noninvasive method that has gained wide attention in the field of neuroscience, and it is potentially able to support multipletarget stimulation by allocating multiple focal points in the brain using an array transducer. However, there are no reports in the literature of the efficacy of this technical concept, and an imaging tool for localizing the stimulation area for evaluating the neural effects in vivo has been lacking. In this study, we designed and fabricated a new system specifically for imaging-guided dualtarget neuromodulation. The design of the array transducer and overall system is described in detail. The stimulation points were selectable on a B-mode image. In vivo experiments were carried out in mice, in which forelimbs shaking responses and electromyo-graphy outcomes were induced by changing the stimulation targets. The system could be a valuable tool for imaging-guided multiple-target stimulation in various neuroscience applications.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/14344]
专题	深圳先进技术研究院_医工所
推荐引用方式 GB/T 7714	Wang, Congzhi,Li, Guofeng,Qiu, Weibao,et al. Imaging-Guided Dual-Target Neuromodulation of the Mouse Brain Using Array Ultrasound[J]. IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL,2018.
APA	Wang, Congzhi.,Li, Guofeng.,Qiu, Weibao.,Hong, Jiehan.,Jiang, Qiuju.,...&Zheng, Hairong.(2018).Imaging-Guided Dual-Target Neuromodulation of the Mouse Brain Using Array Ultrasound.IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL.
MLA	Wang, Congzhi,et al."Imaging-Guided Dual-Target Neuromodulation of the Mouse Brain Using Array Ultrasound".IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL (2018).