Cumulative dose of radiation therapy of hepatocellular carcinoma patients and its deterministic relation to radiation-induced liver disease

	Cumulative dose of radiation therapy of hepatocellular carcinoma patients and its deterministic relation to radiation-induced liver disease
	Yin, Yong; Li, Deng-Wang; Xing, Lei; Huang, Pu; Yu, Gang; Kapp, Daniel S.; Bian, Xue-Feng; Ma, Chang-Sheng; Li, Hong-Sheng; Chen, Jin-Hu
刊名	MEDICAL DOSIMETRY
	2018
文献子类	期刊论文
英文摘要	This study aimed to investigate the relationship between dose and radiation-induced liver disease (RILD) in patients with hepatocellular carcinoma (HCC) receiving 3-dimensional conformal radiotherapy (3DCRT). Twenty-three patients with HCC who received conventional fractionated 3DCRT, including 7 who were diagnosed with classic RILD, were enrolled in this retrospective investigation. Cone-beam computed tomography (CBCT) scans were acquired at the time of treatment for each patient. The beams from each patient's treatment plan were applied to each pretreatment CBCT (the modified CBCT or mCBCT) to construct the delivered dose distribution of the day considering inter-treatment anatomy changes. The daily doses were summed together with the help of deformable image registration (DIR) to obtain the adjusted cumulative dose (D-adjusted). The dose changes to the normal liver between the original planned dose (D-plan) and D-adjusted were evaluated by V20, V30, V40, and the mean dose to normal liver (MDTNL). Univariate analysis was performed to identify the significant dose changes. Among the 23 patients, the liver V20, V30, V40, and MDTNL showed significant differences between D-plan and D-adjusted, with average values of these parameters increased by 4.1%, 4.7%, 4.5%, and 3.9 Gy, respectively (p < 0.05). The adjusted liver dose in 21 patients (91%) was higher than the planned value. For patients without and with RILD,the MDTNL was increased on average by 3.5 Gy and 4.7 Gy, and normal tissue complication probability (NTCP) increased on average by 2.8% and 7.5%, respectively. Our study found that the adjusted cumulative dose based on calculations using pretreatment mCBCT differs significantly from planned dose; the use of the dosimetric results of the initial plan was found to be less predictive of RILD as compared with D-adjusted. Determination of a reconstructed D-adjusted using the mCBCT scans are more accurate in predicting RILD and has the potential to reduce the risk of RILD. (C) 2017 American Association of Medical Dosimetrists.
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/14254]
专题	深圳先进技术研究院_医工所
推荐引用方式 GB/T 7714	Yin, Yong,Li, Deng-Wang,Xing, Lei,et al. Cumulative dose of radiation therapy of hepatocellular carcinoma patients and its deterministic relation to radiation-induced liver disease[J]. MEDICAL DOSIMETRY,2018.
APA	Yin, Yong.,Li, Deng-Wang.,Xing, Lei.,Huang, Pu.,Yu, Gang.,...&Yang, Yong.(2018).Cumulative dose of radiation therapy of hepatocellular carcinoma patients and its deterministic relation to radiation-induced liver disease.MEDICAL DOSIMETRY.
MLA	Yin, Yong,et al."Cumulative dose of radiation therapy of hepatocellular carcinoma patients and its deterministic relation to radiation-induced liver disease".MEDICAL DOSIMETRY (2018).