Broadband graphene-based photoacoustic microscopy with high sensitivity.

	Broadband graphene-based photoacoustic microscopy with high sensitivity.
	Zhu, Siwei; Yuan, Xiaocong; Yang, Fan; Song, Wei; Zhang, Chonglei; Min, Changjun; Fang, Hui; Du, Luping; Wu, Peng; Zheng, Wei
刊名	NANOSCALE
	2018
文献子类	期刊论文
英文摘要	Photoacoustic microscopy (PAM) enables the measurement of properties associated with optical absorption within tissues and complements sophisticated technologies employing optical microscopy. An inadequate frequency response as determined by a piezoelectric ultrasonic transducer results, however, in poor depth resolution and inaccurate measurements of the coefficients of optical absorption. We developed a PAM system configured as an attenuated total reflectance sensor with a ten-layer graphene film sandwiched between a prism and water (the coupling medium) for photoacoustic (PA) wave detection. Transients of the PA pressure cause perturbations in the refractive index of the water thereby changing the polarization-dependent absorption of the graphene film. The signal in PA detection involves recording the difference in the temporal-varying reflectance intensity between the two orthogonally polarized probe beams. The graphene-based sensor has an estimated noise-equivalent-pressure sensitivity of similar to 550 Pa over an approximately linear pressure response from 11.0 kPa to 55.0 kPa. Moreover, it enables a much broader PA bandwidth detection of up to similar to 150 MHz, primarily dominated by a highly localized evanescent field. From the strong optical absorption of inherent hemoglobin, in vivo label-free PAM imaging provided a three-dimensional viewing of the microvasculature of a mouse ear. These results suggest great potential for graphene-based PAM in biomedical investigations, such as microcirculation studies.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/14211]
专题	深圳先进技术研究院_医工所
推荐引用方式 GB/T 7714	Zhu, Siwei,Yuan, Xiaocong,Yang, Fan,et al. Broadband graphene-based photoacoustic microscopy with high sensitivity.[J]. NANOSCALE,2018.
APA	Zhu, Siwei.,Yuan, Xiaocong.,Yang, Fan.,Song, Wei.,Zhang, Chonglei.,...&Li, Changhui.(2018).Broadband graphene-based photoacoustic microscopy with high sensitivity..NANOSCALE.
MLA	Zhu, Siwei,et al."Broadband graphene-based photoacoustic microscopy with high sensitivity.".NANOSCALE (2018).