Identification of differentially expressed genes response to TCDD in rat brain after long-term low-dose exposure

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Identification of differentially expressed genes response to TCDD in rat brain after long-term low-dose exposure
	Zhang, Songyan; Chen, Yangsheng; Xu, Li; Xie, Heidi Q. H.; Xu, Tuan; Fu, Hualing; Sha, Rui; Xia, Yingjie; Zhao, Bin
刊名	JOURNAL OF ENVIRONMENTAL SCIENCES
	2017-10-28
卷号	62 期号:0 页码:92-99
关键词	Tcdd Long-term Exposure Neurotoxicity Microarray Neuroinflammation
英文摘要	Several cohort studies have reported that dioxin and dioxin-like polychlorinated biphenyls might impair the nervous system and lead to neurological or neurodegenerative diseases in the elder people, but there is limited research on the involved mechanism. By using microarray analysis, we figured out the differentially expressed genes between brain samples from SD rats after low-dose (0.1 mu g/(kg.bw)) dioxin exposure for six months and controls. To investigate the function changes in the course of dioxin exposure, Gene Ontology (GO) annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed on the differentially expressed genes. And the changes of several picked genes have been verified by real-time PCR. A total of 145 up-regulated and 64 down-regulated genes were identified. The metabolic processes, interleukin-1 secretion and production were significantly associated with the differentially expressed genes. And the genes regulated by dioxin also clustered to cholinergic synapse and long-term potentiation. Candidate biomarker genes such as egr1, gad2, gabrb3, abca1, ccr5 and pycard may be toxicological targets for dioxin. Furthermore, synaptic plasticity and neuro-immune system may be two principal affected areas by dioxin. (C) 2017 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/39332]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Zhang, Songyan,Chen, Yangsheng,Xu, Li,et al. Identification of differentially expressed genes response to TCDD in rat brain after long-term low-dose exposure[J]. JOURNAL OF ENVIRONMENTAL SCIENCES,2017,62(0):92-99.
APA	Zhang, Songyan.,Chen, Yangsheng.,Xu, Li.,Xie, Heidi Q. H..,Xu, Tuan.,...&Zhao, Bin.(2017).Identification of differentially expressed genes response to TCDD in rat brain after long-term low-dose exposure.JOURNAL OF ENVIRONMENTAL SCIENCES,62(0),92-99.
MLA	Zhang, Songyan,et al."Identification of differentially expressed genes response to TCDD in rat brain after long-term low-dose exposure".JOURNAL OF ENVIRONMENTAL SCIENCES 62.0(2017):92-99.