Mechanisms involved in inflammatory pulmonary fibrosis induced by lunar dust simulant in rats

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	Mechanisms involved in inflammatory pulmonary fibrosis induced by lunar dust simulant in rats
	Liu JG(刘金国)3 ; Zhang, Xiaoping 1,5; Li, Xiongyao 4; Zhou, Baichu 2; Lv, Zengjing 2; Sun Y(孙燕)2,3,5
刊名	Environmental Toxicology
	2019
卷号	34 期号:2 页码:131-140
关键词	fibrosis inflammation lunar dust lung oxidative stress
ISSN号	1520-4081
产权排序	1
英文摘要	Lunar dust is one of the biggest risk factors in the future manned exploration mission. Much is not known about the pulmonary toxicity of lunar dust. The aim of this study was to evaluate the lung inflammation and oxidative stress induced by subacute exposure to lunar dust stimulant (LDS) in rats. Wistar rats were intratracheally administered LDS, twice a week for 3 weeks. Inflammatory cell counting and cytokine assays using bronchoalveolar lavage fluid (BALF) were performed. Lung tissues were processed for histopathological examination and immunohistochemical staining. Biomarkers of oxidative stress and genes and proteins related to inflammation and fibrosis in lung tissue were also determined. The neutrophil count in the BALF of LDS-exposed groups was higher than that in controls.
资助项目	Doctoral Scientific Research Fund of Liaoning Provincial Science and Technology Department[20170520437] ; National Natural Science Foundation of China[51775541] ; Open Projects Funding of Lunar and Planetary Science Laboratory, MUST Partner Laboratory of Key Laboratory of Lunar and Deep Space Exploration, CAS[119/2017/A3] ; Science and Technology Development Fund (FDCT) of Macau[020/2014/A1] ; Science and Technology Research Fund of Shenyang Medical College[20171020]
WOS关键词	NF-KAPPA-B ; PARTICULATE MATTER ; TNF-ALPHA ; MARTIAN DUSTS ; TOXICITY ; MICE ; PARTICLES ; EXPOSURE ; EXPRESSION ; RESPONSES
WOS研究方向	Environmental Sciences & Ecology ; Toxicology ; Water Resources
语种	英语
WOS记录号	WOS:000455775800004
资助机构	Doctoral Scientific Research Fund of Liaoning Provincial Science and Technology Department ; National Natural Science Foundation of China ; Open Projects Funding of Lunar and Planetary Science Laboratory, MUST Partner Laboratory of Key Laboratory of Lunar and Deep Space Exploration, CAS ; Science and Technology Development Fund (FDCT) of Macau ; Science and Technology Research Fund of Shenyang Medical College
内容类型	期刊论文
源URL	[http://ir.sia.cn/handle/173321/23681]
专题	沈阳自动化研究所_空间自动化技术研究室
通讯作者	Liu JG(刘金国); Sun Y(孙燕)
作者单位	1.Lunar and Planetary Science Laboratory, Macau University of Science and Technology, China 2.College of Basic Medical Sciences, Shenyang Medical College, Shenyang, China 3.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China 4.Center for Lunar and Planetary Sciences, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang, China 5.Lunar and Planetary Science Laboratory, MUST-Partner Laboratory of Key Laboratory of Lunar and Deep Space Exploration, CAS, China
推荐引用方式 GB/T 7714	Liu JG,Zhang, Xiaoping,Li, Xiongyao,et al. Mechanisms involved in inflammatory pulmonary fibrosis induced by lunar dust simulant in rats[J]. Environmental Toxicology,2019,34(2):131-140.
APA	Liu JG,Zhang, Xiaoping,Li, Xiongyao,Zhou, Baichu,Lv, Zengjing,&Sun Y.(2019).Mechanisms involved in inflammatory pulmonary fibrosis induced by lunar dust simulant in rats.Environmental Toxicology,34(2),131-140.
MLA	Liu JG,et al."Mechanisms involved in inflammatory pulmonary fibrosis induced by lunar dust simulant in rats".Environmental Toxicology 34.2(2019):131-140.