Construction of Microenvironment Structures for the Study of Cell Behavior using DMD-based Optical Projection Lithography

CORC > 沈阳自动化研究所 > 中国科学院沈阳自动化研究所 > 机器人学研究室

	Construction of Microenvironment Structures for the Study of Cell Behavior using DMD-based Optical Projection Lithography
	Ge ZX(葛治星)1,2; Yu HB(于海波)2 ; Yang WG(杨文广)2; Liu LQ(刘连庆)2
	2018
会议日期	July 23-26, 2018
会议地点	Tyndall Natl Inst, Cork, IRELAND
关键词	DOPL system microfabrication rapid pattern cell-cell interaction cell viability
页码	1-5
英文摘要	The construction of the microenvironment is of great importance for the study of cell behaviors such as motility and viability. The morphology and mechanical properties of cells can be affected by the microenvironment and interactions between cells. There have been numerous studies on cell-cell and cell-microenvironment interactions. However, these studies are generally time-consuming and complicated for the following reasons: firstly, constructing the microenvironment is complex, as the microenvironment itself is complicated; secondly, the internal characteristics of different components of the microenvironment are highly variable and difficult to simulate. Using a digital micromirror device (DMD)-based optical projection lithography system, we have developed a new method for cell studies: by employing a digital dynamic mask, poly(ethylene glycol) dimethacrylate (PEGDMA)-based hydrogels could be easily designed with a wide variety of patterns. Those structures can be rationally designed to be functional, as different modules can mimic the microenvironment and restrict the migration of cells. Furthermore, 4% paraformaldehyde can be mixed into the PEGDMA and cured using UV exposure. Paraformaldehyde in hydrogels had a moderate impact on the viability of cells.
源文献作者	IEEE, Univ Coll Cork, Sci Fdn Ireland
产权排序	1
会议录	2018 IEEE 18th International Conference on Nanotechnology (IEEE-NANO)
会议录出版者	IEEE
会议录出版地	New York
语种	英语
ISSN号	1944-9399
ISBN号	978-1-5386-5336-4
WOS记录号	WOS:000458785600026
内容类型	会议论文
源URL	[http://ir.sia.cn/handle/173321/24240]
专题	沈阳自动化研究所_机器人学研究室
通讯作者	Yu HB(于海波); Liu LQ(刘连庆)
作者单位	1.University of Chinese Academy of Sciences, Beijing 100049, China 2.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China
推荐引用方式 GB/T 7714	Ge ZX,Yu HB,Yang WG,et al. Construction of Microenvironment Structures for the Study of Cell Behavior using DMD-based Optical Projection Lithography[C]. 见:. Tyndall Natl Inst, Cork, IRELAND. July 23-26, 2018.