Functional annotation of extensively and divergently expressed miRNAs in suprachiasmatic nucleus of Clock(Delta 19) mutant mice | |
Wang, Yanli1; Lv, Ke2; Chen, Hailong2; Zhao, Mei3; Ji, Guohua2; Zhang, Yongliang1; Cao, Hongqing2; Kan, Guanghan2; Li, Yinghui1,2; Qu, Lina2 | |
刊名 | BIOSCIENCE REPORTS |
2018-12-21 | |
卷号 | 38页码:11 |
ISSN号 | 0144-8463 |
DOI | 10.1042/BSR20180233 |
产权排序 | 3 |
文献子类 | article |
英文摘要 | Circadian locomotor output cycles kaput protein (CLOCK) is a core transcription factor of complex integrated feedback loops in mammalian circadian clock. More genes have been reported to be regulated by CLOCK, however little is known about the role of CLOCK-mediated miRNAs. To dissect this, we used microarray analysis to measure miRNAs expression in suprachiasmatic nuclei (SCN) of wild-type (WT) and Clock(Delta 19) mutant mice at two different time points. We found that miRNAs regulation in two time points was extensive (nearly 75% of the miRNAs expressed at each time point), and very little overlap, with only six miRNAs in common. Besides this, the predicted CLOCK regulated miRNAs at two time points participated in extremely diverse pathways. We validated nine miRNAs (miR-125a-3p, miR-144, miR-199a-5p, miR-199b*, miR-200a, miR-200b, miR-203, miR-449a, and miR-96), which were involved in the same signaling pathway-hippo signaling pathway. The rhythms of these miRNAs showed a broad distribution of phase, amplitude, and waveform in Clock mutation. And further analysis indicated that there may be three models of miRNA-mediated circadian rhythms and hippo signaling pathway. MiRNA, the small player, may play a hub role in connecting circadian rhythms and other pathways via its multiple target genes networks. |
WOS关键词 | CIRCADIAN-CLOCK ; CELL AUTONOMY ; PROTEIN ; TIME |
WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
语种 | 英语 |
出版者 | PORTLAND PRESS LTD |
WOS记录号 | WOS:000454266100010 |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/28025] |
专题 | 心理研究所_健康与遗传心理学研究室 |
通讯作者 | Li, Yinghui; Qu, Lina |
作者单位 | 1.Northwestern Polytech Univ, Sch Life Sci, Xian 710072, Shaanxi, Peoples R China 2.China Astronaut Res & Training Ctr, State Key Lab Space Med Fundamentals & Applicat, Beijing 100094, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Yanli,Lv, Ke,Chen, Hailong,et al. Functional annotation of extensively and divergently expressed miRNAs in suprachiasmatic nucleus of Clock(Delta 19) mutant mice[J]. BIOSCIENCE REPORTS,2018,38:11. |
APA | Wang, Yanli.,Lv, Ke.,Chen, Hailong.,Zhao, Mei.,Ji, Guohua.,...&Qu, Lina.(2018).Functional annotation of extensively and divergently expressed miRNAs in suprachiasmatic nucleus of Clock(Delta 19) mutant mice.BIOSCIENCE REPORTS,38,11. |
MLA | Wang, Yanli,et al."Functional annotation of extensively and divergently expressed miRNAs in suprachiasmatic nucleus of Clock(Delta 19) mutant mice".BIOSCIENCE REPORTS 38(2018):11. |
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