Positive magnetic resonance angiography using ultrafine ferritin-based iron oxide nanoparticles

doi:10.1039/c8nr06812g

CORC > 地质与地球物理研究所 > 中国科学院地质与地球物理研究所 > 中国科学院地球与行星物理重点实验室

	Positive magnetic resonance angiography using ultrafine ferritin-based iron oxide nanoparticles
	Cai, Yao 1,2,3; Wang, Yuqing 4; Xu, Huangtao 1,2,3,5; Cao, Changqian 1,2,3; Zhu, Rixiang 3; Tang, Xu 6; Zhang, Tongwei 1,2; Pan, Yongxin 1,2,3,5
刊名	NANOSCALE
	2019-02-14
卷号	11 期号:6 页码:2644-2654
ISSN号	2040-3364
DOI	10.1039/c8nr06812g
英文摘要	Iron oxide nanoparticles with good biocompatibility can serve as safe magnetic resonance imaging contrast agents. Herein, we report that ultrafine ferritin-based iron oxide (hematite/maghemite) nanoparticles synthesized by controlled biomimetic mineralization using genetically recombinant human H chain ferritin can be used as a positive contrast agent in magnetic resonance angiography. The synthesized magnetoferritin with an averaged core size of 2.2 +/- 0.7 nm (hereafter named M-HFn-2.2) shows a r1 value of 0.86 mM(-1) s(-1) and a r2/r1 ratio of 25.1 at a 7 T magnetic field. Blood pool imaging on mice using the M-HFn-2.2 nanoparticles that were injected through a tail vein by single injection at a dose of 0.54 mM Fe per kg mouse body weight enabled detecting detailed vascular nets at 3 minutes post-injection; the MR signal intensity continuously enhanced up to 2 hours post-injection, which is much longer than that of the commercial magnevist (Gd-DTPA) contrast. Moreover, biodistribution examination indicates that organs such as liver, spleen and kidney safely cleared the injected nanoparticles within one day after the injection, demonstrating no risk of iron overload in test mice. Therefore, this study sheds light on developing high-performance gadolinium free positive magnetic resonance contrast agents for biomedical applications.
资助项目	National Natural Science Foundation of China[41621004] ; National Natural Science Foundation of China[41704072] ; National Natural Science Foundation of China[41330104] ; National Natural Science Foundation of China[41574062] ; Key Program of Chinese Academy of Sciences[QYZDJ-SSW-DQC024] ; China Postdoctoral Science Foundation[2017M610979]
WOS关键词	T-1 CONTRAST AGENTS ; H-FERRITIN ; GADOLINIUM DEPOSITION ; PROTEIN ; FERUMOXYTOL ; PHARMACOKINETICS ; DIAGNOSIS ; NANOCAGES ; PLATFORM ; TUMORS
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000459579400048
资助机构	National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation
内容类型	期刊论文
源URL	[http://ir.iggcas.ac.cn/handle/132A11/90673]
专题	地质与地球物理研究所_中国科学院地球与行星物理重点实验室
通讯作者	Cai, Yao; Pan, Yongxin
作者单位	1.Chinese Acad Sci, Inst Geol & Geophys, Biogeomagnetism Grp, Key Lab Earth & Planetary Phys, Beijing 100029, Peoples R China 2.Chinese Acad Sci, France China Int Lab Evolut & Dev Magnetotact Mul, Beijing 100029, Peoples R China 3.Chinese Acad Sci, Inst Geol & Geophys, PGL, Beijing 100029, Peoples R China 4.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 6.Chinese Acad Sci, Inst Earth Sci, Transmiss Electron Microscope Lab, Beijing 100029, Peoples R China
推荐引用方式 GB/T 7714	Cai, Yao,Wang, Yuqing,Xu, Huangtao,et al. Positive magnetic resonance angiography using ultrafine ferritin-based iron oxide nanoparticles[J]. NANOSCALE,2019,11(6):2644-2654.
APA	Cai, Yao.,Wang, Yuqing.,Xu, Huangtao.,Cao, Changqian.,Zhu, Rixiang.,...&Pan, Yongxin.(2019).Positive magnetic resonance angiography using ultrafine ferritin-based iron oxide nanoparticles.NANOSCALE,11(6),2644-2654.
MLA	Cai, Yao,et al."Positive magnetic resonance angiography using ultrafine ferritin-based iron oxide nanoparticles".NANOSCALE 11.6(2019):2644-2654.