ssDNA-tailorable oxidase-mimicking activity of spinel MnCo2O4 for sensitive biomolecular detection in food sample

doi:10.1016/j.snb.2018.04.150

	ssDNA-tailorable oxidase-mimicking activity of spinel MnCo2O4 for sensitive biomolecular detection in food sample
	Wang, Jianlong 2; Suo, Yourui1 ; Hu, Na 1; Wang, Rong 2; Wang, Jing 2; Liu, Xinnan 2; Zhu, Wenxin 2; Zhang, Wentao 2; Chen, Kai 2; Huang, Lunjie 2
刊名	SENSORS AND ACTUATORS B-CHEMICAL
	2018-09-15
卷号	269 页码:87-95
关键词	Activity Modulation Aptamer Biosensor Food Analysis Nanozyme Oxidase
ISSN号	0925-4005
DOI	10.1016/j.snb.2018.04.150
文献子类	Article
英文摘要	Nanozyme technique with efficient modulating strategies is a promising tool for biocatalytic and biosensing applications, yet insights into target-responsive controllability of oxidase nanozymes remain largely unknown. In this contribution, we report a state-of-art oxidase-like and ssDNA-tunable nanozyme for biomolecular recognition. In detail, the spinel-type manganese cation substituted cobalt oxide (MnCo2O4) submicrospheres can imitate oxidase for efficiently catalytic oxidation of colorimetric substrate, superior to current metal oxide-based oxidase nanozymes. More importantly, the nanozyme activity of spinel MnCo2O4 can be reversibly inhibited by the attachment/detachment of aptamer strands on MnCo2O4 surface via the aptamer-target binding event, enabling a new colorimetric access for detecting biomolecules. Taking highly toxic ochratoxin A (OTA) as model molecule, we can selectively determine OTA in maize samples with a limit of detection (3 delta/S) of 0.08 ng/mL. The unique nanozyme property of spinel MnCo2O4, together with the principle of our approach, reveals the potential of ssDNA-tailorable oxidase nanozymes in biocatalytic and biosensing fields. (C) 2018 Elsevier B.V. All rights reserved.
WOS关键词	PEROXIDASE-LIKE ACTIVITY ; COLORIMETRIC DETECTION ; NANOZYME ACTIVITY ; VISIBLE-LIGHT ; QUANTUM DOTS ; COCOA BEANS ; OCHRATOXIN ; NANOPARTICLES ; DNA ; APTASENSOR
WOS研究方向	Chemistry ; Electrochemistry ; Instruments & Instrumentation
语种	英语
出版者	ELSEVIER SCIENCE SA
WOS记录号	WOS:000433211100012
资助机构	National Natural Science Foundation of China(21675127) ; Fundamental Research Funds for the Central Universities(2014YB093 ; Development Project of Qinghai Key Laboratory(2017-ZJ-Y10) ; 2452015257)
内容类型	期刊论文
源URL	[http://ir.nwipb.ac.cn/handle/363003/13792]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
通讯作者	Wang, Jianlong
作者单位	1.Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Key Lab Qinghai Tibet Plateau Biol Resour, Xining 810008, Qinghai, Peoples R China 2.Northwest A&F Univ, Coll Food Sci & Engn, Yangling 712100, Shaanxi, Peoples R China
推荐引用方式 GB/T 7714	Wang, Jianlong,Suo, Yourui,Hu, Na,et al. ssDNA-tailorable oxidase-mimicking activity of spinel MnCo2O4 for sensitive biomolecular detection in food sample[J]. SENSORS AND ACTUATORS B-CHEMICAL,2018,269:87-95.
APA	Wang, Jianlong.,Suo, Yourui.,Hu, Na.,Wang, Rong.,Wang, Jing.,...&Huang, Lunjie.(2018).ssDNA-tailorable oxidase-mimicking activity of spinel MnCo2O4 for sensitive biomolecular detection in food sample.SENSORS AND ACTUATORS B-CHEMICAL,269,87-95.
MLA	Wang, Jianlong,et al."ssDNA-tailorable oxidase-mimicking activity of spinel MnCo2O4 for sensitive biomolecular detection in food sample".SENSORS AND ACTUATORS B-CHEMICAL 269(2018):87-95.