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	Small size fullerenol nanoparticles inhibit thrombosis and blood coagulation through inhibiting activities of thrombin and fxa
	Xia, Shibo1,2; Li, Juan1; Zu, Mian1; Li, Jinxia1; Liu, Jinke1; Bai, Xue1,2; Chang, Yanan1; Chen, Kui1,2; Gu, Weihong1,2; Zeng, Li3
刊名	Nanomedicine-nanotechnology biology and medicine
	2018-04-01
卷号	14期号:3页码:929-939
关键词	Fullerenols Anticoagulation Thrombin Fxa Ca2+ Inhibition of thrombosis
ISSN号	1549-9634
DOI	10.1016/j.nano.2017.12.013
通讯作者	Zhao, lina(linazhao@ihep.ac.cn) ; Xing, gengyan(xgy1350138@163.com) ; Xing, gengmei(xinggm@ihep.ac.cn)
英文摘要	Thrombus is one of main causes of death in the world and also a vital trouble of biomaterials application in vivo. recently, effect of fullerenol nanomaterials on anticoagulation was found in our research through extension of bleeding times in treated sprague-dawley rats via intravenous injection. inhibiting of fullerenols on thrombosis was ascertained further by thromboembolism model. effects of fullerenols on intrinsic and extrinsic pathway were distinct in prolonging activated partial thromboplastin time and prothrombin time, which supported that fullerenols induced defects in both pathways. inhibited activities of activated coagulation factor x (fxa) and thrombin were verified by experiments in vitro and autodock vina. the results suggest that fullerenols depending on small size and certainly surface property occupied the active domain of fxa and thrombin to block their activity; further, thrombosis was inhibited. this putative mechanism offers an insight into how fullerenol nps were utilized further in biomedical applications. (c) 2018 elsevier inc. all rights reserved.
WOS关键词	PLATELET-AGGREGATION ; ANTITHROMBOTIC ACTIVITIES ; PROCOAGULANT ACTIVITY ; STEM-CELLS ; IN-VITRO ; FIBRINOGEN ; ANTICOAGULANT ; BINDING ; PERMEABILITY ; SUPPRESSION
WOS研究方向	Science & Technology - Other Topics ; Research & Experimental Medicine
WOS类目	Nanoscience & Nanotechnology ; Medicine, Research & Experimental
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000429528900027
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2178169
专题	高能物理研究所
通讯作者	Zhao, Lina; Xing, Gengyan; Xing, Gengmei
作者单位	1.Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing, Peoples R China 2.UCAS, Beijing, Peoples R China 3.Gen Hosp Chinese Peoples Armed Police Forces, Dept Orthoped, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Xia, Shibo,Li, Juan,Zu, Mian,et al. Small size fullerenol nanoparticles inhibit thrombosis and blood coagulation through inhibiting activities of thrombin and fxa[J]. Nanomedicine-nanotechnology biology and medicine,2018,14(3):929-939.
APA	Xia, Shibo.,Li, Juan.,Zu, Mian.,Li, Jinxia.,Liu, Jinke.,...&Xing, Gengmei.(2018).Small size fullerenol nanoparticles inhibit thrombosis and blood coagulation through inhibiting activities of thrombin and fxa.Nanomedicine-nanotechnology biology and medicine,14(3),929-939.
MLA	Xia, Shibo,et al."Small size fullerenol nanoparticles inhibit thrombosis and blood coagulation through inhibiting activities of thrombin and fxa".Nanomedicine-nanotechnology biology and medicine 14.3(2018):929-939.

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