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	Early-life exposure to three size-fractionated ultrafine and fine atmospheric particulates in beijing exacerbates asthma development in mature mice
	Mei, Mei1,2,3,4; Song, Haojun5; Chen, Lina1,2,3,4; Hu, Bin1,2,3,4; Bai, Ru1,2,3,4; Xu, Diandou5; Liu, Ying1,2,3,4; Zhao, Yuliang1,2,3,4; Chen, Chunying1,2,3,4
刊名	Particle and fibre toxicology
	2018-03-14
卷号	15页码:16
关键词	Early-life exposure Particulate matter Adulthood Allergic asthma
ISSN号	1743-8977
DOI	10.1186/s12989-018-0249-1
通讯作者	Chen, chunying(chenchy@nanoctr.cn)
英文摘要	Background: epidemiological studies have suggested that elevated levels of air pollution contribute to an increased incidence or severity of asthma. although late-onset adult asthma seems to be more attributable to environmental risk factors, limited data is available on the impact of early-life exposure to size-fractionated ambient particulate matter (pm) on asthma in adults. we aimed to determine the effect on the development and exacerbation of asthma in the adult after the mice were exposed as juveniles to three size-fractionated ambient particulates collected from beijing. methods: the three size-fractionated ambient particulates were collected from urban beijing in winter, heavily affected by traffic and coal-fired emissions. the typical morphological and major chemical components of the pm were characterized first. oxidative stress and expression of dna methyltransferases (dnmts) were then examined in vitro and in the lungs of mouse pups 48 h after exposure to pm by oropharyngeal aspiration. when the exposed and control juvenile mice matured to adulthood, an antigen-induced asthma model was established and relevant bio-indices were assessed. results: pm with different granularities can induce oxidative stress; in particular, f1, with the smallest size (< 0.49 mu m), decreased the mrna expression of dnmts in vitro and in vivo the most significantly. in an asthma model of adult mice, previous exposure as juveniles to size-fractionated pm caused increased peribronchiolar inflammation, increased airway mucus secretion, and increased production of th2 cytokines and chemokines. in general, f1 and f2 (aerodynamic diameter < 0.95 mu m) particulates affected murine adult asthma development more seriously than f3 (0.95-1.5 mu m). moreover, f1 led to airway inflammation in the form of both increased neutrophils and eosinophils in balf. the activation of the tgf-beta 1/smad2 and smad3/stat3 signaling pathways leading to airway fibrosis was more profoundly induced by f1. conclusion: this study demonstrated that exposure to ambient pm in juvenile mice enhanced adult asthma development, as shown by increased th2 responses, which might be associated with the persistent effects resulting from the oxidative stress and decreased gene expression of dnmts induced by pm exposure. the observed differences between the effects of three size-fractionated particulates were attributed to particle sizes and chemical constituents, including heavy metals and also pahs, since the amounts of pah associated with more severe toxicity were enriched equivalently in the f1 and f2 fractions. relative to the often mentioned pm2.5, pm with an aerodynamic diameter smaller than 0.95 mu m had a more aggravating effect on asthma development.
WOS关键词	DIESEL EXHAUST PARTICLES ; OXIDATIVE STRESS ; AIR-POLLUTION ; CHILDHOOD ASTHMA ; EPIGENETIC MECHANISMS ; DNA METHYLATION ; MOUSE MODEL ; CELLS ; MATTER ; INFLAMMATION
WOS研究方向	Toxicology
WOS类目	Toxicology
语种	英语
出版者	BIOMED CENTRAL LTD
WOS记录号	WOS:000427768800001
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2178099
专题	高能物理研究所
通讯作者	Chen, Chunying
作者单位	1.Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China 3.Natl Ctr Nanosci & Technol China, Beijing Key Lab Ambient Particles Hlth Effects &, Beijing 100190, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100190, Peoples R China 5.Chinese Acad Sci, Inst High Energy Phys, Div Nucl Technol & Applicat, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Mei, Mei,Song, Haojun,Chen, Lina,et al. Early-life exposure to three size-fractionated ultrafine and fine atmospheric particulates in beijing exacerbates asthma development in mature mice[J]. Particle and fibre toxicology,2018,15:16.
APA	Mei, Mei.,Song, Haojun.,Chen, Lina.,Hu, Bin.,Bai, Ru.,...&Chen, Chunying.(2018).Early-life exposure to three size-fractionated ultrafine and fine atmospheric particulates in beijing exacerbates asthma development in mature mice.Particle and fibre toxicology,15,16.
MLA	Mei, Mei,et al."Early-life exposure to three size-fractionated ultrafine and fine atmospheric particulates in beijing exacerbates asthma development in mature mice".Particle and fibre toxicology 15(2018):16.

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