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	Ph-triggered peptide self-assembly for targeting imaging and therapy toward angiogenesis with enhanced signals
	Qian, Yixia1,2; Wang, Weizhi1; Wang, Zihua1; Jia, Xiangqian1; Han, Qiuju1; Rostami, Iman1; Wang, Yuehua1; Hu, Zhiyuan1,3,4
刊名	Acs applied materials & interfaces
	2018-03-07
卷号	10期号:9页码:7871-7881
关键词	Ph-triggered Vegfr2 Self-assembly Biaimaging Cancer therapy
ISSN号	1944-8244
DOI	10.1021/acsami.8b00583
通讯作者	Wang, weizhi(wangwz@nanoctr.cn) ; Hu, zhiyuan(huzy@nanoctr.cn)
英文摘要	Mild acidic environment and angiogenesis are two typical characteristics of tumor. the specific response toward both lower ph and angiogenesis may enhance the targeting ability both for drug and diagnostic probe delivery. herein, we present a kind of dual responding self-assembled nanotransformation material that is tumor angiogenesis targeting and ph triggered based on amphiphilic conjugation between peptides (stp) and aromatic molecules (tetraphenyl-ethylene (tpe)). the morphology of the self-assembled peptide conjugates is responsibly changed from nanoparticles in neutral condition to nanofibers in acidic condition, which "turn on" the in vivo targeting imaging and accelerate the efficient drug delivery and in vivo therapy. on the basis of the well-controlled nanotransformation both in vitro and in vivo, we envisioned the successful demonstration of the responding materials would open a new avenue in turn on targeting imaging diagnostics and specific cancer therapeutics.
WOS关键词	ANTICANCER DRUG-DELIVERY ; TUMOR MICROENVIRONMENT ; CANCER-THERAPY ; CELLS ; NANOPARTICLES ; FABRICATION ; BIOMATERIALS ; RECEPTORS ; MICELLES ; BIOLOGY
WOS研究方向	Science & Technology - Other Topics ; Materials Science
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000427204100037
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2178098
专题	高能物理研究所
通讯作者	Wang, Weizhi; Hu, Zhiyuan
作者单位	1.Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, CAS Key Lab Standardizat & Measurement Nanotechno, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Univ Chinese Acad Sci, Sinodanish Coll, Beijing 100049, Peoples R China 4.Fujian Med Univ, Sch Basic Med Sci, Ctr Neurosci Res, Fuzhou 350108, Fujian, Peoples R China
推荐引用方式 GB/T 7714	Qian, Yixia,Wang, Weizhi,Wang, Zihua,et al. Ph-triggered peptide self-assembly for targeting imaging and therapy toward angiogenesis with enhanced signals[J]. Acs applied materials & interfaces,2018,10(9):7871-7881.
APA	Qian, Yixia.,Wang, Weizhi.,Wang, Zihua.,Jia, Xiangqian.,Han, Qiuju.,...&Hu, Zhiyuan.(2018).Ph-triggered peptide self-assembly for targeting imaging and therapy toward angiogenesis with enhanced signals.Acs applied materials & interfaces,10(9),7871-7881.
MLA	Qian, Yixia,et al."Ph-triggered peptide self-assembly for targeting imaging and therapy toward angiogenesis with enhanced signals".Acs applied materials & interfaces 10.9(2018):7871-7881.

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