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	Transferrin adsorbed on pegylated gold nanoparticles and its relevance to targeting specificity
	Cai, Chengxu1,2; Wang, Mingzhe1,2; Wang, Xinyi1; Wang, Bing3; Chen, Hanqing3; Chen, Jian3; Chen, Chunying1; Feng, Weiyue3
刊名	Journal of nanoscience and nanotechnology
	2018-08-01
卷号	18期号:8页码:5306-5313
关键词	Gold nanoparticle Transferrin Pegylation Adsorption Target delivery
ISSN号	1533-4880
DOI	10.1166/jnn.2018.15435
通讯作者	Chen, chunying() ; Feng, weiyue()
英文摘要	Polyethylene glycol (peg) has been frequently used for surface modification of nanoparticles (nps) to reduce non-specific binding of proteins on nps. the investigation of protein absorption on pegylated nanoparticles is necessary. in the work, the conjugation of transferrin (tf) to pegylated aunps via adsorption or bonding was studied. the 13 nm aunps were coated with various molecular weight (300, 2000, 5000) carboxyl and methoxy peg thiol. the presence of tf on pegylated aunp was characterized by dynamic light scattering (dls) and infrared spectroscopy (ir). the data of ir confirmed the presence of tf on pegylated aunps. the diameter decrease of pegylated aunps after tf adsorption was observed by dls measurement, which is attributed to competitive adsorption between tf and peg molecules. these phenomena may be important to the preservation of tf targeting specificity on pegylated aunps.
WOS关键词	PROTEIN CORONA ; POLYETHYLENE-GLYCOL ; SURFACE ; RECEPTOR ; NANOCARRIERS ; ANTIBODIES ; ADSORPTION ; IMPACT ; CELLS
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
语种	英语
出版者	AMER SCIENTIFIC PUBLISHERS
WOS记录号	WOS:000426059800015
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2178001
专题	高能物理研究所
通讯作者	Chen, Chunying; Feng, Weiyue
作者单位	1.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst High Energy Phys, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Cai, Chengxu,Wang, Mingzhe,Wang, Xinyi,et al. Transferrin adsorbed on pegylated gold nanoparticles and its relevance to targeting specificity[J]. Journal of nanoscience and nanotechnology,2018,18(8):5306-5313.
APA	Cai, Chengxu.,Wang, Mingzhe.,Wang, Xinyi.,Wang, Bing.,Chen, Hanqing.,...&Feng, Weiyue.(2018).Transferrin adsorbed on pegylated gold nanoparticles and its relevance to targeting specificity.Journal of nanoscience and nanotechnology,18(8),5306-5313.
MLA	Cai, Chengxu,et al."Transferrin adsorbed on pegylated gold nanoparticles and its relevance to targeting specificity".Journal of nanoscience and nanotechnology 18.8(2018):5306-5313.

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