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	Biodegradable moox nanoparticles with efficient near-infrared photothermal and photodynamic synergetic cancer therapy at the second biological window
	Yin, Wenyan1; Bao, Tao1; Zhang, Xiao1; Gao, Qin1; Yu, Jie1; Dong, Xinghua1; Yan, Liang1; Gu, Zhanjun1; Zhao, Yuliang1,2
刊名	Nanoscale
	2018-01-21
卷号	10期号:3页码:1517-1531
ISSN号	2040-3364
DOI	10.1039/c7nr07927c
通讯作者	Gu, zhanjun(zjgu@ihep.ac.cn)
英文摘要	Near-infrared (nir) laser induced phototherapy has been considered as a noninvasive option for cancer therapy. herein, we report plasmonic pegylated molybdenum oxide nanoparticles (peg-moox nps) that were synthesized by using a facile hydrothermal method. the peg-moox nps exhibit broad absorption at the nir biological window and remarkable photothermal conversion ability in the first (808 nm) and the second (1064 nm) windows. moreover, the biocompatible peg-moox nps exhibit effective cellular uptake and could be eliminated gradually from the liver and spleen in mice. studies on the therapeutic effects of these nps under 808 and 1064 nm exposures with mild hyperthermia are conducted. according to the result, exposure to 1064 nm irradiation can not only effectively convert light into heat but also sensitize the formation of reactive oxygen species (ros), which exert dramatic cancer cell death and suppression in vivo due to the synergic effect of photothermal therapy (ptt) and photodynamic therapy (pdt). in marked contrast, 808 nm irradiation can only execute limited ptt to cancer cells, showing a relatively low inhibition rate in vitro and in vivo. this biodegradable moox nanoplatform with synergetic ptt and pdt functionalities upon 1064 nm irradiation provided emerging opportunities for the phototherapy of cancer in nanomedicine.
WOS关键词	SURFACE-PLASMON RESONANCES ; IN-VIVO ; GOLD NANORODS ; SEMICONDUCTOR NANOCRYSTALS ; MILD HYPERTHERMIA ; TUNGSTEN-OXIDE ; SINGLET OXYGEN ; 1064 NM ; LIGHT ; NANOMATERIALS
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000423259000069
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2177947
专题	高能物理研究所
通讯作者	Gu, Zhanjun
作者单位	1.Chinese Acad Sci, Inst High Energy Phys, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China 2.Natl Ctr Nanosci & Technol China, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Yin, Wenyan,Bao, Tao,Zhang, Xiao,et al. Biodegradable moox nanoparticles with efficient near-infrared photothermal and photodynamic synergetic cancer therapy at the second biological window[J]. Nanoscale,2018,10(3):1517-1531.
APA	Yin, Wenyan.,Bao, Tao.,Zhang, Xiao.,Gao, Qin.,Yu, Jie.,...&Zhao, Yuliang.(2018).Biodegradable moox nanoparticles with efficient near-infrared photothermal and photodynamic synergetic cancer therapy at the second biological window.Nanoscale,10(3),1517-1531.
MLA	Yin, Wenyan,et al."Biodegradable moox nanoparticles with efficient near-infrared photothermal and photodynamic synergetic cancer therapy at the second biological window".Nanoscale 10.3(2018):1517-1531.

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