QQ客服 官方微博 反馈留言

	Neurochemical changes in the hippocampus and prefrontal cortex associated with electroacupuncture for learning and memory impairment
	He, Jian1; Zhao, Congkuai2; Liu, Weilin1; Huang, Jia1; Liang, Shengxiang3,4; Chen, Lidian1,2; Tao, Jing1,2
刊名	International journal of molecular medicine
	2018-02-01
卷号	41期号:2页码:709-716
关键词	Electroacupuncture Ischemia and reperfusion Learning and memory impairment Magnetic resonance spectroscopy
ISSN号	1107-3756
DOI	10.3892/ijmm.2017.3287
通讯作者	Chen, lidian(cld@fjtcm.edu.cn) ; Tao, jing(taojing01@163.com)
英文摘要	Electroacupuncture (ea) has been widely used to treat cognitive impairment following cerebral ischemia. however, the functional mechanisms of ea have not been fully elucidated. the aim of the present study was to investigate whether ea at the gv 20 and du 24 acupoints can improve the learning and memory ability via alteration of the neurochemical metabolism in the hippocampus (hpc) and prefrontal cortex (pfc) of rats with ischemia and reperfusion (i/r) injury. sprague-dawley male rats were randomly divided into three groups, namely the sham group (n=12), the middle cerebral artery occlusion (mcao) group (n=12) and the ea treatment (mcao + ea) group (n=12). mcao was performed to establish the left focal cerebral i/r injury model, and the gv 20 and du 24 acupoints were then stimulated with ea for 30 min per time, once daily, for 7 consecutive days. the morris water maze (mwm) test was used to assess learning and memory ability. t2-weighted imaging was used to assess the cerebral infarct volume. magnetic resonance spectroscopy was used to assess neurochemical metabolism of hpc and pfc. the neurological scores of the mcao + ea group were significantly reduced compared with those of the mcao group 7 days after ea treatment (p<0.01). the escape latency of the mwm test in the mcao + ea group was found to be shorter compared with that in the mcao group (p<0.01). the number of rats crossing through the platform area was significantly higher in the mcao + ea group compared with that in the mcao group (p<0.01). the cerebral infarct volume was also decreased in the mcao + ea group compared with the mcao group (p<0.05). the ratios of n-acetylaspartate (naa)/creatine (cr) and choline (cho)/cr of left-to-right hpc were increased in the mcao + ea group compared with the mcao group; however, the ratio of glutamate (glu)/cr did not change significantly (p>0.05). the ratios of naa/cr, cho/cr and glu/cr of left-to-right pfc were elevated (p<0.05). in conclusion, ea at the gv 20 and du 24 acupoints may ameliorate learning and memory ability, possibly through increasing the levels of naa and cho in the hpc and pfc of rats with i/r injury.
WOS关键词	MAGNETIC-RESONANCE-SPECTROSCOPY ; CEREBRAL-ARTERY OCCLUSION ; REDUCED N-ACETYLASPARTATE ; REPERFUSION INJURED RATS ; COGNITIVE IMPAIRMENT ; ALZHEIMERS-DISEASE ; VASCULAR DEMENTIA ; ISCHEMIC-STROKE ; IN-VIVO ; METABOLISM
WOS研究方向	Research & Experimental Medicine
WOS类目	Medicine, Research & Experimental
语种	英语
出版者	SPANDIDOS PUBL LTD
WOS记录号	WOS:000423222200012
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2177885
专题	高能物理研究所
通讯作者	Chen, Lidian; Tao, Jing
作者单位	1.Fujian Univ Tradit Chinese Med, Coll Rehabil Med, 1 Huatuo Rd, Fuzhou 350122, Fujian, Peoples R China 2.Fujian Key Lab Rehabil Technol, Fuzhou 350003, Fujian, Peoples R China 3.Zhengzhou Univ, Coll Phys Sci & Technol, Zhengzhou 450001, Henan, Peoples R China 4.Chinese Acad Sci, Inst High Energy Phys, Div Nucl Technol & Applicat, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	He, Jian,Zhao, Congkuai,Liu, Weilin,et al. Neurochemical changes in the hippocampus and prefrontal cortex associated with electroacupuncture for learning and memory impairment[J]. International journal of molecular medicine,2018,41(2):709-716.
APA	He, Jian.,Zhao, Congkuai.,Liu, Weilin.,Huang, Jia.,Liang, Shengxiang.,...&Tao, Jing.(2018).Neurochemical changes in the hippocampus and prefrontal cortex associated with electroacupuncture for learning and memory impairment.International journal of molecular medicine,41(2),709-716.
MLA	He, Jian,et al."Neurochemical changes in the hippocampus and prefrontal cortex associated with electroacupuncture for learning and memory impairment".International journal of molecular medicine 41.2(2018):709-716.

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。