QQ客服 官方微博 反馈留言

	Nanoantagonists with nanophase-segregated surfaces for improved cancer immunotherapy
	Ma, Yang1,2; Qiao, Sheng-Lin1,2; Wang, Yi1,2; Lin, Yao-Xin1; An, Hong-Wei1; Wu, Xiao-Chun3; Wang, Lei1; Wang, Hao1,2
刊名	Biomaterials
	2018-02-01
卷号	156页码:248-257
关键词	Thermosensitive polymer Nanophase segregation Immune checkpoint Cancer Immunotherapy
ISSN号	0142-9612
DOI	10.1016/j.biomaterials.2017.11.048
通讯作者	Wang, hao(wanghao@nanoctr.cn)
英文摘要	The blockade of pd-1/pd-l1 interaction by peptide antagonists can unleash and enhance pre-existing anti-cancer immune responses of t cells to eradicate cancer cells. however, low proteolytic stability is the "achilles' heel" of peptides. here, we first report a nanoantagonist with a physiological temperature sensitive nanophase-segregated surface that exhibits significantly enhanced blood circulation, peptide stability and pd-l1 immune checkpoint blockade efficacy. thermosensitive polymers with different phase transition temperatures (tt) are used to form the nanophase-segregated surface on an au nanorod core. importantly, the nanophase-segregated surface aids the nanoantagonist to resist protein adsorption and enhance the systemic stability of the linked peptides. finally, the as-designed nanoantagonist effectively blocks pd-1/pd-l1 interaction in vitro and in vivo, enhances the pre-existing cd8(+) t cell tumor destruction capability and inhibits tumor growth. this study offers a new strategy for designing nano formulations for cancer immunotherapy. (c) 2017 elsevier ltd. all rights reserved.
WOS关键词	CHECKPOINT BLOCKADE ; GOLD NANOPARTICLES ; IN-VIVO ; RADICAL POLYMERIZATION ; MONOCLONAL-ANTIBODIES ; THERAPEUTIC PEPTIDES ; IMMUNITY ; MICELLES ; B7-H1 ; SHELL
WOS研究方向	Engineering ; Materials Science
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000419539100019
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2177868
专题	高能物理研究所
通讯作者	Wang, Hao
作者单位	1.Natl Ctr Nanosci & Technol NCNST, CAS Key Lab Biomed Effects Nanomat & Nanosafety, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China 2.UCAS, Beijing 100049, Peoples R China 3.Natl Ctr Nanosci & Technol NCNST, CAS Key Lab Standardizat & Measurement Nanotechno, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Ma, Yang,Qiao, Sheng-Lin,Wang, Yi,et al. Nanoantagonists with nanophase-segregated surfaces for improved cancer immunotherapy[J]. Biomaterials,2018,156:248-257.
APA	Ma, Yang.,Qiao, Sheng-Lin.,Wang, Yi.,Lin, Yao-Xin.,An, Hong-Wei.,...&Wang, Hao.(2018).Nanoantagonists with nanophase-segregated surfaces for improved cancer immunotherapy.Biomaterials,156,248-257.
MLA	Ma, Yang,et al."Nanoantagonists with nanophase-segregated surfaces for improved cancer immunotherapy".Biomaterials 156(2018):248-257.

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。