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	Photothermal effect enhanced cascade targeting strategy for improved pancreatic cancer therapy by gold nanoshell@mesoporous silica nanorod
	Zhao, Ruifang1,2,3; Han, Xuexiang1,2,3; Li, Yiye1,3; Wang, Hai1,3; Ji, Tianjiao1,4; Zhao, Yuliang1,3; Nie, Guangjun1,3
刊名	Acs nano
	2017-08-01
卷号	11期号:8页码:8103-8113
关键词	Pancreatic cancer Gold nanoshell Tumor targeting Photothermal effect Chemotherapeutic sensitivity Combination therapy
ISSN号	1936-0851
DOI	10.1021/acsnano.7b02918
通讯作者	Li, yiye(liyy@nanoctr.cn) ; Nie, guangjun(niegj@nanoctr.cn)
英文摘要	Pancreatic cancer, one of the leading causes of cancer-related mortality, is characterized by desmoplasia and hypovascular cancerous tissue, with a 5 year survival rate of <8%. to overcome the severe resistance of pancreatic cancer to conventional therapies, we synthesized gold nanoshell-coated rod-like mesoporous silica (gnrs) nanoparticles which integrated cascade tumor targeting (mediated by photothermal effect and molecular receptor binding) and photothermal treatment enhanced gemcitabine chemotherapy, under mild near-infrared laser irradiation condition. gnrs significantly improved gemcitabine penetration and accumulation in tumor tissues, thus destroying the dense stroma barrier of pancreatic cancer and reinforcing chemosensitivity in mice. our current findings strongly support the notion that further development of this integrated plasmonic photothermal strategy may represent a promising translational nanoformulation for effective treatment of pancreatic cancer with integral cascade tumor targeting strategy and enhanced drug delivery efficacy.
WOS关键词	TRANSFERRIN RECEPTOR ; DRUG-DELIVERY ; POLYMER NANOPARTICLES ; GEMCITABINE ; HYPERTHERMIA ; TUMORS ; CELLS ; SIZE ; TOMOGRAPHY ; STATISTICS
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000408520900060
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2177783
专题	高能物理研究所
通讯作者	Li, Yiye; Nie, Guangjun
作者单位	1.CAS Ctr Excellence Nanosci, Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Harvard Med Sch, Childrens Hosp Boston, Div Crit Care Med, Dept Anesthesiol,Lab Biomat & Drug Delivery, 300 Longwood Ave, Boston, MA 02115 USA
推荐引用方式 GB/T 7714	Zhao, Ruifang,Han, Xuexiang,Li, Yiye,et al. Photothermal effect enhanced cascade targeting strategy for improved pancreatic cancer therapy by gold nanoshell@mesoporous silica nanorod[J]. Acs nano,2017,11(8):8103-8113.
APA	Zhao, Ruifang.,Han, Xuexiang.,Li, Yiye.,Wang, Hai.,Ji, Tianjiao.,...&Nie, Guangjun.(2017).Photothermal effect enhanced cascade targeting strategy for improved pancreatic cancer therapy by gold nanoshell@mesoporous silica nanorod.Acs nano,11(8),8103-8113.
MLA	Zhao, Ruifang,et al."Photothermal effect enhanced cascade targeting strategy for improved pancreatic cancer therapy by gold nanoshell@mesoporous silica nanorod".Acs nano 11.8(2017):8103-8113.

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