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	Aggregated single-walled carbon nanotubes attenuate the behavioural and neurochemical effects of methamphetamine in mice
	Xue, Xue1,2; Yang, Jing-Yu3; He, Yi4; Wang, Li-Rong1,2,5; Liu, Ping3; Yu, Li-Sha3; Bi, Guo-Hua4; Zhu, Ming-Ming3; Liu, Yue-Yang3; Xiang, Rong-Wu6
刊名	Nature nanotechnology
	2016-07-01
卷号	11期号:7页码:613-+
ISSN号	1748-3387
DOI	10.1038/nnano.2016.23
通讯作者	Xi, zheng-xiong(zxi@mail.nih.gov)
英文摘要	Methamphetamine (meth) abuse is a serious social and health problem worldwide. at present, there are no effective medications to treat meth addiction(1). here, we report that aggregated single-walled carbon nanotubes (aswnts) significantly inhibited meth self-administration, meth-induced conditioned place preference and meth- or cue-induced relapse to drug-seeking behaviour in mice. the use of aswnts alone did not significantly alter the mesolimbic dopamine system, whereas pretreatment with aswnts attenuated meth-induced increases in extracellular dopamine in the ventral striatum. electrochemical assays suggest that aswnts facilitated dopamine oxidation. in addition, aswnts attenuated meth-induced increases in tyrosine hydroxylase or synaptic protein expression. these findings suggest that aswnts may have therapeutic effects for treatment of meth addiction by oxidation of meth-enhanced extracellular dopamine in the striatum.
WOS关键词	ELECTROCHEMICAL SENSORS ; CEREBRAL-CORTEX ; DOPAMINE ; RECEPTORS ; RAT ; BIOMOLECULES ; PLASTICITY ; OXYTOCIN ; NEURONS ; COCAINE
WOS研究方向	Science & Technology - Other Topics ; Materials Science
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000379506600012
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2177777
专题	高能物理研究所
通讯作者	Xi, Zheng-Xiong
作者单位	1.Chinese Acad Sci, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China 2.Natl Ctr Nanosci & Technol China, Beijing 100190, Peoples R China 3.Shenyang Pharmaceut Univ, Dept Pharmacol, Shenyang 110016, Peoples R China 4.NIDA, Intramural Res Program, NIH, Baltimore, MD 21224 USA 5.Natl Ctr Nanosci & Technol China, CAS Key Lab Standardizat & Measurement Nanotechno, Beijing 100190, Peoples R China 6.Shenyang Pharmaceut Univ, Dept Biopharmaceut Informat, Shenyang 110016, Peoples R China 7.Chinese Acad Sci, Inst Biophys, State Key Lab Biomacromol, Beijing 100101, Peoples R China 8.Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Xue, Xue,Yang, Jing-Yu,He, Yi,et al. Aggregated single-walled carbon nanotubes attenuate the behavioural and neurochemical effects of methamphetamine in mice[J]. Nature nanotechnology,2016,11(7):613-+.
APA	Xue, Xue.,Yang, Jing-Yu.,He, Yi.,Wang, Li-Rong.,Liu, Ping.,...&Liang, Xing-Jie.(2016).Aggregated single-walled carbon nanotubes attenuate the behavioural and neurochemical effects of methamphetamine in mice.Nature nanotechnology,11(7),613-+.
MLA	Xue, Xue,et al."Aggregated single-walled carbon nanotubes attenuate the behavioural and neurochemical effects of methamphetamine in mice".Nature nanotechnology 11.7(2016):613-+.

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