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	Amf responsive dox-loaded magnetic microspheres: transmembrane drug release mechanism and multimodality postsurgical treatment of breast cancer
	Xue, Weiming1; Liu, Xiao-Li2,3; Ma, Heping1; Xie, Wensheng4; Huang, Saipeng1; Wen, Huiyun1; Jing, Guangyin5; Zhao, Lingyun4; Liang, Xing-Jie3; Fan, Hai Ming2
刊名	Journal of materials chemistry b
	2018-04-21
卷号	6期号:15页码:2289-2303
ISSN号	2050-750X
DOI	10.1039/c7tb03206d
通讯作者	Fan, hai ming(fanhm@nwu.edu.cn)
英文摘要	Dox-loaded magnetic alginate-chitosan microspheres (dm-acmss) were developed as a model system to evaluate alternating magnetic field (amf)-responsive, chemo-thermal synergistic therapy for multi-modality postsurgical treatment of breast cancer. this multimodality function can be achieved by the combination of dox for chemotherapy, with superparamagnetic iron oxide nanoparticles (spions) as magnetic hyperthermia agents and drug release trigger. both moieties are encapsulated in acmss which also allow on-demand drug release. it is demonstrated that the optimized spion content in dm-acmss is about 0.29 mg fe, at which dm-acmss could exhibit the best hyperthermia performance. under a remote amf, dm-acms can quickly reach a 22.5% cumulative drug release in the tumor site within 10 min upon exposure under amf, whereas only 0.2% dox is released in the absence of amf. furthermore, a comparison study of amf and water bath as heating source indicates that the cumulative drug release amount upon amf exposure is twice that by water bath heating. further analysis revealed that the amf stimulated drug release is driven by both thermal and concentration gradient from inside to outside, which can be well-described by the coupling mechanism of mass and heat transfer using the soret diffusion model. in vitro cytotoxicity tests on mcf-7 breast cancer cells show that the combined therapy based on dm-acmss leads to 95.5% cell death, about 1.5-fold and 1.1-fold higher than that of single magnetic hyperthermia or chemotherapy, respectively. the in vivo anti-tumor effect on tumor-bearing mice demonstrates that the residual tumor disappears in 12 days after chemo-thermal synergistic treatment using dm-acmss, and there is no recurrence in the entire experiment period (40 days) as compared to 25 days recurrence for single-modality treatment. our results not only provide an innovative dm-acmss system as a stimuli-responsive, synergistic chemo-thermal therapy platform for efficient reduction in the recurrence of breast cancer, but also provide insight into the intricate interplay of the functional components in magnetic hydrogel microspheres.
WOS关键词	DELIVERY-SYSTEM ; CELLULAR UPTAKE ; GRAPHENE OXIDE ; HIGH-FREQUENCY ; RISK-FACTORS ; IRON-OXIDE ; NANOPARTICLES ; RECURRENCE ; HYDROGEL ; ALGINATE
WOS研究方向	Materials Science
WOS类目	Materials Science, Biomaterials
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000431111700011
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2177620
专题	高能物理研究所
通讯作者	Fan, Hai Ming
作者单位	1.Northwest Univ, Sch Chem Engn, Xian 710069, Shaanxi, Peoples R China 2.Northwest Univ, Coll Chem & Mat Sci, Minist Educ, Key Lab Synthet & Nat Funct Mol Chem, Xian 710069, Shaanxi, Peoples R China 3.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 4.Tsinghua Univ, Sch Mat Sci & Engn, State Key Lab New Ceram & Fine Proc, Key Lab Adv Mat, Beijing 100084, Peoples R China 5.Northwest Univ, State Key Lab Incubat Base Photoelect Technol & F, Dept Phys, Xian 710069, Shanxi, Peoples R China
推荐引用方式 GB/T 7714	Xue, Weiming,Liu, Xiao-Li,Ma, Heping,et al. Amf responsive dox-loaded magnetic microspheres: transmembrane drug release mechanism and multimodality postsurgical treatment of breast cancer[J]. Journal of materials chemistry b,2018,6(15):2289-2303.
APA	Xue, Weiming.,Liu, Xiao-Li.,Ma, Heping.,Xie, Wensheng.,Huang, Saipeng.,...&Fan, Hai Ming.(2018).Amf responsive dox-loaded magnetic microspheres: transmembrane drug release mechanism and multimodality postsurgical treatment of breast cancer.Journal of materials chemistry b,6(15),2289-2303.
MLA	Xue, Weiming,et al."Amf responsive dox-loaded magnetic microspheres: transmembrane drug release mechanism and multimodality postsurgical treatment of breast cancer".Journal of materials chemistry b 6.15(2018):2289-2303.

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