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	Significant enhancement of photothermal and photoacoustic efficiencies for semiconducting polymer nanoparticles through simply molecular engineering
	Dong, Tao1,2,3,4; Wen, Kaikai1,2,3; Chen, Jun5; Xie, Jin5; Fan, Weili6; Ma, Han7; Yang, Lei1,2,3; Wu, Xiaoxi1,2,3; Xu, Fujian6; Peng, Aidong1,2,3
刊名	Advanced functional materials
	2018-06-06
卷号	28期号:23页码:11
关键词	Molecular engineering Photoacoustic imaging Photothermal therapy Semiconducting polymer nanoparticles Tumors
ISSN号	1616-301X
DOI	10.1002/adfm.201800135
通讯作者	Huang, hui(huihuang@ucas.ac.cn)
英文摘要	Semiconducting polymer nanoparticles (sp nps) are employed as efficient nanoagents for "all-in-one" theranostic nanoplatforms with dual photoacoustic imaging (pai) and photothermal therapy (ptt) functions based on their photothermal conversion effect. however, the mechanisms of tuning the ptt efficiency are still elusive, though several sp nps with high photothermal efficiency are reported. herein, two donor-acceptor (d-a) sp nps ptigsvs and piigsvs with the same donor unit but different acceptor units are designed and synthesized. through tuning the acceptor unit, ptigsvs shows more planar backbone structure, stronger d-a strength, redshifted absorption, enhanced extinction efficient, weakened emission properties, and more efficient nonradiative decay in comparison to the polymeric analogue piigsvs. thus, ptigsvs nps present much higher photothermal conversion efficiencies (74%) than piigsvs nps (11%), resulting in significantly enhanced in vitro and in vivo pai and ptt performance. this contribution demonstrates that ptigsvs nps are superior pa/ptt agents for effective cancer theranostic and shed light on understanding the relationship between molecular structures and photothermal effect of cps.
WOS关键词	MULTIFUNCTIONAL THERANOSTIC AGENT ; CANCER-THERAPY ; LIVING MICE ; ORGANIC NANOPARTICLES ; CONJUGATED POLYMERS ; MOS2 NANOSHEETS ; CONTRAST AGENTS ; DRUG-DELIVERY ; CARBON DOTS ; TUMOR
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000434207800009
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2177504
专题	高能物理研究所
通讯作者	Huang, Hui
作者单位	1.Univ Chinese Acad Sci, Coll Mat Sci & Optoelect Technol, Beijing 100049, Peoples R China 2.Univ Chinese Acad Sci, CAS Key Lab Vacuum Phys, Beijing 100049, Peoples R China 3.Univ Chinese Acad Sci, CAS Ctr Excellence Topol Quantum Computat, Beijing 100049, Peoples R China 4.Jinzhong Univ, Sch Chem & Chem Engn, Jinzhong 030600, Peoples R China 5.Chinese Acad Sci, Inst High Energy Phys, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China 6.Beijing Univ Chem Technol, Beijing Adv Innovat Ctr Soft Matter Sci & Engn, Beijing Lab Biomed Mat, Key Lab Carbon Fiber & Funct Polymers,Minist Educ, Beijing 100029, Peoples R China 7.Sun Yat Sen Univ, Affiliated Hosp 3, Dept Dermatol, 600 Tianhe Rd, Guangzhou 510630, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Dong, Tao,Wen, Kaikai,Chen, Jun,et al. Significant enhancement of photothermal and photoacoustic efficiencies for semiconducting polymer nanoparticles through simply molecular engineering[J]. Advanced functional materials,2018,28(23):11.
APA	Dong, Tao.,Wen, Kaikai.,Chen, Jun.,Xie, Jin.,Fan, Weili.,...&Huang, Hui.(2018).Significant enhancement of photothermal and photoacoustic efficiencies for semiconducting polymer nanoparticles through simply molecular engineering.Advanced functional materials,28(23),11.
MLA	Dong, Tao,et al."Significant enhancement of photothermal and photoacoustic efficiencies for semiconducting polymer nanoparticles through simply molecular engineering".Advanced functional materials 28.23(2018):11.

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