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	Synthesis of bsa-coated bioi@bi2s3 semiconductor heterojunction nanoparticles and their applications for radio/photodynamic/photothermal synergistic therapy of tumor
	Guo, Zhao1,2; Zhu, Shuang1; Yong, Yuan1,3; Zhang, Xiao1,2,4; Dong, Xinghua1,2; Du, Jiangfeng1,5; Xie, Jiani1,2; Wang, Qing6; Gu, Zhanjun1,2; Zhao, Yuliang1,2,4
刊名	Advanced materials
	2017-11-27
卷号	29期号:44页码:12
关键词	Bismuth oxyiodide Photodynamic therapy Photothermal therapy Radiotherapy Semiconductors
ISSN号	0935-9648
DOI	10.1002/adma.201704136
通讯作者	Gu, zhanjun(zjgu@ihep.ac.cn) ; Zhao, yuliang(yuliangzhao@ihep.ac.cn)
英文摘要	Developing an effective theranostic nanoplatform remains a great challenge for cancer diagnosis and treatment. here, bioi@bi2s3@bsa (bovine serum albumin) semiconductor heterojunction nanoparticles (shnps) for triple-combination radio/photodynamic/photothermal cancer therapy and multimodal computed tomography/photoacoustic (ct/pa) bioimaging are reported. on the one hand, shnps possess strong x-ray attenuation capability since they contain high-z elements, and thus they are anticipated to be a very competent candidate as radio-sensitizing materials for radiotherapy enhancement. on the other hand, as a semiconductor, the as-prepared shnps offer an extra approach for reactive oxygen species generation based on electron-hole pair under the irradiation of x-ray through the photodynamic therapy process. this x-ray excited photodynamic therapy obviously has better penetration depth in bio-tissue. what's more, the shnps also possess well photothermal conversion efficiency for photothermal therapy, because bi2s3 is a thin band semiconductor with strong near-infrared absorption that can cause local overheat. in vivo tumor ablation studies show that synergistic radio/photodynamic/photothermal therapy achieves more significant therapeutic effect than any single treatment. in addition, with the strong x-ray attenuation and high near-infrared absorption, the as-obtained shnps can also be applied as a multimodal contrast agent in ct/pa imaging.
WOS关键词	PHOTODYNAMIC THERAPY ; GOLD NANOPARTICLES ; RADIATION-THERAPY ; CANCER-TREATMENT ; QUANTUM DOTS ; PHOTOTHERMAL THERAPY ; NECK-CANCER ; RADIOTHERAPY ; RADIOSENSITIZATION ; OXYGEN
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000415905200025
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2177472
专题	高能物理研究所
通讯作者	Gu, Zhanjun; Zhao, Yuliang
作者单位	1.Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China 2.Univ Chinese Acad Sci, Coll Mat Sci & Optoelect Technol, Beijing 100049, Peoples R China 3.Southwest Minzu Univ, Coll Chem & Environm Protect Engn, Chengdu 610041, Sichuan, Peoples R China 4.Chinese Acad Sci, Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China 5.Shanxi Med Univ, Hosp 1, Dept Med Imaging, Taiyuan 030001, Shanxi, Peoples R China 6.Shandong Univ Sci & Technol, Inst Nano Engn, Sch Mat Sci & Engn, Qingdao 266590, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Guo, Zhao,Zhu, Shuang,Yong, Yuan,et al. Synthesis of bsa-coated bioi@bi2s3 semiconductor heterojunction nanoparticles and their applications for radio/photodynamic/photothermal synergistic therapy of tumor[J]. Advanced materials,2017,29(44):12.
APA	Guo, Zhao.,Zhu, Shuang.,Yong, Yuan.,Zhang, Xiao.,Dong, Xinghua.,...&Zhao, Yuliang.(2017).Synthesis of bsa-coated bioi@bi2s3 semiconductor heterojunction nanoparticles and their applications for radio/photodynamic/photothermal synergistic therapy of tumor.Advanced materials,29(44),12.
MLA	Guo, Zhao,et al."Synthesis of bsa-coated bioi@bi2s3 semiconductor heterojunction nanoparticles and their applications for radio/photodynamic/photothermal synergistic therapy of tumor".Advanced materials 29.44(2017):12.

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