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	Mitochondria-targeting au nanoclusters enhance radiosensitivity of cancer cells
	Fang, Xu1; Wang, Yaling2; Ma, Xiaochuan3; Li, Yingying1; Zhang, Zhaolei1; Xiao, Zhisheng1; Liu, Lijia1; Gao, Xueyun2; Liu, Jian1
刊名	Journal of materials chemistry b
	2017-06-14
卷号	5期号:22页码:4190-4197
ISSN号	2050-750X
DOI	10.1039/c7tb00422b
通讯作者	Ma, xiaochuan(xcma@suda.edu.cn) ; Liu, jian(jliu@suda.edu.cn)
英文摘要	Fradiotherapy is an important technology for the clinical treatment of cancer, but the patients suffer from the severe side effects after exposure to radiation. there is an urgent need to develop theranostic agents with excellent imaging capability and effective radiosensitization in order to minimize x-ray irradiation. herein, we report an approach to synthesize peptide-templated au nanoclusters (auncs) for theranostic radiosensitization. a new peptide (ccykfr) is designed for the preparation of auncs with uniform size distribution and fluorescence (656 nm) of high photostability. ccykfr-auncs feature highly efficient targeting/accumulation on mitochondria after endocytosis. with a series of experiments, we demonstrate that ccykfr-auncs irradiated by 4 gy x-rays can introduce a burst of mitoros and severe dna damage leading to cancer cell death. this study presents an important strategy to design theranostic nanomaterials with improved radiosensitization for the development of new anti-cancer therapies.
WOS关键词	GOLD NANOPARTICLES ; X-RAY ; THERAPY ; RADIOTHERAPY ; DNA ; CLUSTERS ; MECHANISMS ; DAMAGE ; ROS ; RADIATION
WOS研究方向	Materials Science
WOS类目	Materials Science, Biomaterials
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000403026400019
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2177292
专题	高能物理研究所
通讯作者	Ma, Xiaochuan; Liu, Jian
作者单位	1.Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Suzhou 215123, Jiangsu, Peoples R China 2.Chinese Acad Sci, Inst High Energy Phys, Beijing 100049, Peoples R China 3.Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, Collaborat Innovat Ctr Radiat Med, Jiangsu Higher Educ Inst, Suzhou 215123, Jiangsu, Peoples R China
推荐引用方式 GB/T 7714	Fang, Xu,Wang, Yaling,Ma, Xiaochuan,et al. Mitochondria-targeting au nanoclusters enhance radiosensitivity of cancer cells[J]. Journal of materials chemistry b,2017,5(22):4190-4197.
APA	Fang, Xu.,Wang, Yaling.,Ma, Xiaochuan.,Li, Yingying.,Zhang, Zhaolei.,...&Liu, Jian.(2017).Mitochondria-targeting au nanoclusters enhance radiosensitivity of cancer cells.Journal of materials chemistry b,5(22),4190-4197.
MLA	Fang, Xu,et al."Mitochondria-targeting au nanoclusters enhance radiosensitivity of cancer cells".Journal of materials chemistry b 5.22(2017):4190-4197.

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