| Terrylenediimide-based intrinsic theranostic nanomedicines with high photothermal conversion efficiency for photoacoustic imaging-guided cancer therapy | |
| Zhang, Shaobo1; Guo, Weisheng2,3; Wei, Jie1; Li, Chan2,3; Liang, Xing-Jie2,3,4; Yin, Meizhen1 | |
| 刊名 | Acs nano
 |
| 2017-04-01 | |
| 卷号 | 11期号:4页码:3797-3805 |
| 关键词 | Terrylenediimides Theranostic nanomedicine Self-assembly Photoacoustic imaging Photothermal therapy |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/acsnano.6b08720 |
| 通讯作者 | Liang, xing-jie(liangxj@nanoctr.cn) ; Yin, meizhen(yinmz@mail.buct.edu.cn) |
| 英文摘要 | Activatable theranostic nanomedicines involved in photothermal therapy (ptt) have received constant attention as promising alternatives to traditional therapies in clinic. however, the theranostic nanomedicines widely suffer from instability and complicated nanostructures, which hamper potential clinical applications. herein, we demonstrated a terrylenediimide (tdi)-poly(acrylic acid) (tpa)-based nanomedicine (tnm) platform used as an intrinsic theranostic agent. as an exploratory paradigm in seeking biomedical applications, tdi was modified with poly(acrylic acid)s (paas), resulting in eight armed, star-like tpas composed of an outside hydrophilic paa corona and an inner hydrophobic tdi core. tnms were readily fabricated via spontaneous self-assembly. without additional vehicle and cargo, the as-prepared tnms possessed a robust nanostructure and high photothermal conversion efficiency up to approximately 41%. the intrinsic theranostic properties of tnms for use in photoacoustic (pa) imaging by a multispectral optoacoustic tomography system and in mediating photoinduced tumor ablation were intensely explored. our results suggested that the tnms could be successfully exploited as intrinsic theranostic agents for pa imaging-guided efficient tumor ptt. thus, these tnms hold great potential for (pre)clinical translational development. |
| WOS关键词 | INDOCYANINE GREEN ICG ; IN-VIVO ; QUANTUM DOTS ; POLYMER NANOPARTICLES ; GOLD NANOPARTICLES ; CONTRAST AGENTS ; INSECT PESTS ; ORGANIC-DYE ; IRON-OXIDE ; FLUORESCENCE |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000400233200038 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2177234 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Liang, Xing-Jie; Yin, Meizhen |
| 作者单位 | 1.Beijing Univ Chem Technol, Beijing Lab Biomed Mat, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China 2.Chinese Acad Sci, Ctr Excellence Nanosci, Beijing 100190, Peoples R China 3.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Lab Controllable Nanopharmaceut, Beijing 100190, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Shaobo,Guo, Weisheng,Wei, Jie,et al. Terrylenediimide-based intrinsic theranostic nanomedicines with high photothermal conversion efficiency for photoacoustic imaging-guided cancer therapy[J]. Acs nano,2017,11(4):3797-3805. |
| APA | Zhang, Shaobo,Guo, Weisheng,Wei, Jie,Li, Chan,Liang, Xing-Jie,&Yin, Meizhen.(2017).Terrylenediimide-based intrinsic theranostic nanomedicines with high photothermal conversion efficiency for photoacoustic imaging-guided cancer therapy.Acs nano,11(4),3797-3805. |
| MLA | Zhang, Shaobo,et al."Terrylenediimide-based intrinsic theranostic nanomedicines with high photothermal conversion efficiency for photoacoustic imaging-guided cancer therapy".Acs nano 11.4(2017):3797-3805. |
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