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	Distinct roles of dopamine receptors in the lateral thalamus in a rat model of decisional impulsivity
	Wang, Zhiyan1,2,3,4; Liang, Shengxiang5; Yu, Shuangshuang1,2,3,4; Xie, Tong1,2,3,4; Wang, Baicheng1,2,3,4; Wang, Junkai1,2,3,4; Li, Yijing1,2,3,4; Shan, Baoci5; Cui, Cailian1,2,3,4
刊名	Neuroscience bulletin
	2017-08-01
卷号	33期号:4页码:413-422
关键词	Lateral thalamus Decisional impulsivity D1 receptor D2 receptor
ISSN号	1673-7067
DOI	10.1007/s12264-017-0146-x
通讯作者	Cui, cailian(clcui@bjmu.edu.cn)
英文摘要	The thalamus and central dopamine signaling have been shown to play important roles in high-level cognitive processes including impulsivity. however, little is known about the role of dopamine receptors in the thalamus in decisional impulsivity. in the present study, rats were tested using a delay discounting task and divided into three groups: high impulsivity (hi), medium impulsivity (mi), and low impulsivity (li). subsequent in vivo voxel-based magnetic resonance imaging revealed that the hi rats displayed a markedly reduced density of gray matter in the lateral thalamus compared with the li rats. in the mi rats, the dopamine d1 receptor antagonist sch23390 or the d2 receptor antagonist eticlopride was microinjected into the lateral thalamus. sch23390 significantly decreased their choice of a large, delayed reward and increased their omission of lever presses. in contrast, eticlopride increased the choice of a large, delayed reward but had no effect on the omissions. together, our results indicate that the lateral thalamus is involved in decisional impulsivity, and dopamine d1 and d2 receptors in the lateral thalamus have distinct effects on decisional impulsive behaviors in rats. these results provide a new insight into the dopamine signaling in the lateral thalamus in decisional impulsivity.
WOS关键词	REACTION-TIME-TASK ; D2 RECEPTORS ; ORBITOFRONTAL CORTEX ; NUCLEUS-ACCUMBENS ; ATTENTIONAL PERFORMANCE ; BASOLATERAL AMYGDALA ; RETICULAR NUCLEUS ; PRIMATE THALAMUS ; CHOICE ; MODULATION
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000406345600006
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2177170
专题	高能物理研究所
通讯作者	Cui, Cailian
作者单位	1.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China 2.Peking Univ, Sch Basic Med Sci, Dept Neurobiol, Beijing 100191, Peoples R China 3.Minist Educ, Key Lab Neurosci, Beijing 100191, Peoples R China 4.Minist Publ Hlth, Beijing 100191, Peoples R China 5.Chinese Acad Sci, Inst High Energy Phys, Div Nucl Technol & Applicat, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wang, Zhiyan,Liang, Shengxiang,Yu, Shuangshuang,et al. Distinct roles of dopamine receptors in the lateral thalamus in a rat model of decisional impulsivity[J]. Neuroscience bulletin,2017,33(4):413-422.
APA	Wang, Zhiyan.,Liang, Shengxiang.,Yu, Shuangshuang.,Xie, Tong.,Wang, Baicheng.,...&Cui, Cailian.(2017).Distinct roles of dopamine receptors in the lateral thalamus in a rat model of decisional impulsivity.Neuroscience bulletin,33(4),413-422.
MLA	Wang, Zhiyan,et al."Distinct roles of dopamine receptors in the lateral thalamus in a rat model of decisional impulsivity".Neuroscience bulletin 33.4(2017):413-422.

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