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	Ultrasmall superparamagnetic iron oxide nanoparticle for t-2-weighted magnetic resonance imaging
	Wang, Yaling1; Xu, Chao1,3; Chang, Yanan1; Zhao, Lina1; Zhang, Kai4; Zhao, Yuliang1; Gao, Fuping1; Gao, Xueyun2
刊名	Acs applied materials & interfaces
	2017-08-30
卷号	9期号:34页码:28959-28966
关键词	Bsa Biomineralization Ultrasmall superparamagnetic iron oxide T-2-weighted magnetic resonance imaging
ISSN号	1944-8244
DOI	10.1021/acsami.7b10030
通讯作者	Gao, xueyun(gaoxy@ihep.ac.cn)
英文摘要	A facile method to synthesize ultrasmall-sized super magnetic iron oxide nanoparticles with good monodispersity and high relaxivity is desired for magnetic resonance imaging (mri) technology. herein, we have developed a one-step method to direct the formation of superparamagnetic iron oxide nanoparticle (ubspio) using albumin under mild conditions. the resulting ubspio possess ultrasmall size (4.78 +/- 0.55 nm) and super high mr relaxivity (444.56 +/- 8.82 mm(-1) s(-1)). after grafted by the luteinizing hormone release hormone peptide (lhrh), the ubspio could targeted and accumulated in the tumor site. finally, the ubspios had good stability and did not induce cytotoxicity in vitro or major organ toxicity in vivo. the ubspios are promising contrast agents for mri.
WOS关键词	MRI CONTRAST AGENTS ; BIOMEDICAL APPLICATIONS ; DRUG-DELIVERY ; CELLS ; TOMOGRAPHY ; RELAXIVITY ; THERAPY ; DESIGN ; NANOPROBES ; LHRH-PE40
WOS研究方向	Science & Technology - Other Topics ; Materials Science
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000409395500090
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2177044
专题	高能物理研究所
通讯作者	Gao, Xueyun
作者单位	1.Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing, Peoples R China 2.Beijing Univ Technol, Dept Chem & Chem Engn, Beijing, Peoples R China 3.Shandong Agr Univ, Coll Chem & Mat Sci, Tai An, Shandong, Peoples R China 4.Chinese Acad Sci, Inst High Energy Phys, Beijing Synchrotron Radiat Facil, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Wang, Yaling,Xu, Chao,Chang, Yanan,et al. Ultrasmall superparamagnetic iron oxide nanoparticle for t-2-weighted magnetic resonance imaging[J]. Acs applied materials & interfaces,2017,9(34):28959-28966.
APA	Wang, Yaling.,Xu, Chao.,Chang, Yanan.,Zhao, Lina.,Zhang, Kai.,...&Gao, Xueyun.(2017).Ultrasmall superparamagnetic iron oxide nanoparticle for t-2-weighted magnetic resonance imaging.Acs applied materials & interfaces,9(34),28959-28966.
MLA	Wang, Yaling,et al."Ultrasmall superparamagnetic iron oxide nanoparticle for t-2-weighted magnetic resonance imaging".Acs applied materials & interfaces 9.34(2017):28959-28966.

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