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	Polymeric nanoparticles promote macrophage reversal from m2 to m1 phenotypes in the tumor microenvironment
	Wang, Yi1,2; Lin, Yao-Xin1,2; Qiao, Sheng-Lin1,2; An, Hong-Wei1,2; Ma, Yang1,2; Qiao, Zeng-Ying1; Rajapaksha, R. P. Yeshan J.1,2; Wang, Hao1,2
刊名	Biomaterials
	2017
卷号	112页码:153-163
关键词	Nanoparticles Self-assembly Cancer Immunotherapy Macrophage
ISSN号	0142-9612
DOI	10.1016/j.biomaterials.2016.09.034
通讯作者	Wang, hao(wanghao@nanoctr.cn)
英文摘要	Immunotherapy has shown promising treatment effects for a variety of cancers. however, the immune treatment efficiency for solid tumors is limited owing to insufficient infiltration of immune cells into solid tumors. the conversion of tumor-supportive macrophages to tumor-suppressive macrophages, inducing the functional reversal of macrophages, is an effective method and contributes to a subsequent antitumor response. the current challenge in the field is the poor distribution and systemic side effects associated with the use of cytokines. as a solution to this issue, we designed and synthesized microenvironment-responsive nanoparticles (p) with il-12 payload (il-12 subset of p1). these nanoparticles could promote the systemic administration and release of il-12 in the tumor microenvironment, and the locally responsive property of il-12 subset of p1 could subsequently re-educate tumor-associated macrophages (tams). in particular, our results illustrated the great therapeutic effects derived from the functional conversion of macrophages. our strategy was to design a microenvironment-responsive material for local macrophage modification to overcome the physiological barrier of solid tumors. the shifting of macrophage phenotypes via il-12 subset of p1 achieved immunomodulation in the microenvironment for cancer therapy, with negligible cytotoxicity. we expect that the functional regulation of tams by ph-responsive nanomaterials is a promising therapeutic approach for cancer immunotherapy. (c) 2016 elsevier ltd. all rights reserved.
WOS关键词	ANTIGEN-PRESENTING CELLS ; CANCER-IMMUNOTHERAPY ; IN-VIVO ; ADAPTIVE IMMUNITY ; DENDRITIC CELLS ; ACTIVATION ; DELIVERY ; PH ; RESISTANCE ; ANTITUMOR
WOS研究方向	Engineering ; Materials Science
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000389166700014
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2176620
专题	高能物理研究所
通讯作者	Wang, Hao
作者单位	1.Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, CAS Ctr Excellence Nanosci, 11 Beiyitiao, Beijing, Peoples R China 2.Univ Chinese Acad Sci UCAS, 19A Yuquan Rd, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Wang, Yi,Lin, Yao-Xin,Qiao, Sheng-Lin,et al. Polymeric nanoparticles promote macrophage reversal from m2 to m1 phenotypes in the tumor microenvironment[J]. Biomaterials,2017,112:153-163.
APA	Wang, Yi.,Lin, Yao-Xin.,Qiao, Sheng-Lin.,An, Hong-Wei.,Ma, Yang.,...&Wang, Hao.(2017).Polymeric nanoparticles promote macrophage reversal from m2 to m1 phenotypes in the tumor microenvironment.Biomaterials,112,153-163.
MLA	Wang, Yi,et al."Polymeric nanoparticles promote macrophage reversal from m2 to m1 phenotypes in the tumor microenvironment".Biomaterials 112(2017):153-163.

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