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	Thermo-controlled in situ phase transition of polymer-peptides on cell surfaces for high-performance proliferative inhibition
	Qiao, Sheng-Lin1,2; Wang, Yi1,2; Lin, Yao-Xin1,2; An, Hong-Wei1,2; Ma, Yang1,2; Li, Li-Li1; Wang, Lei1; Wang, Hao1
刊名	Acs applied materials & interfaces
	2016-07-13
卷号	8期号:27页码:17016-17022
关键词	Self-assembly Polymer Peptide Temperature-responsive Cancer
ISSN号	1944-8244
DOI	10.1021/acsami.6b04580
通讯作者	Wang, lei(wanglei@nanoctr.cn) ; Wang, hao(wanghao@nanoctr.cn)
英文摘要	We herein report a thermocontrolled strategy for realizing in situ conformational transition of polymer peptide conjugates at cell surfaces to manipulate and monitor her2 receptor clustering, which finally result in effective breast cancer cell proliferation inhibition. functional paring motifs (hbp) are covalently linked to a synthetic thermoresponsive polymer pnipaam to incorporate temperature control properties to her2 targeting peptide. at 40 degrees c, the pnipaam polymers collapse and act as a "shield" to block the aggregation of hbp. upon cooling to 35 degrees c, polymers are in their extended state and hbp are expose in aqueous and aggregate subsequently with enhanced fluorescence, allowing for promoting and in situ monitoring of receptor clustering. ultimately, her2 receptor clustering leads to cytoplasmic domain phosphorylation, which further results in effective cancer cell proliferation inhibition. we envision that this useful approach has the potential to be applied for molecule-targeted tumor therapy.
WOS关键词	RECEPTOR TYROSINE KINASES ; MICELLES ; DELIVERY ; NANOPARTICLES ; VIVO ; EFFICIENCY ; RETENTION ; THERAPY
WOS研究方向	Science & Technology - Other Topics ; Materials Science
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000379794100002
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2176597
专题	高能物理研究所
通讯作者	Wang, Lei; Wang, Hao
作者单位	1.Natl Ctr Nanosci & Technol NCNST, CAS Ctr Excellence Nanosci, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Qiao, Sheng-Lin,Wang, Yi,Lin, Yao-Xin,et al. Thermo-controlled in situ phase transition of polymer-peptides on cell surfaces for high-performance proliferative inhibition[J]. Acs applied materials & interfaces,2016,8(27):17016-17022.
APA	Qiao, Sheng-Lin.,Wang, Yi.,Lin, Yao-Xin.,An, Hong-Wei.,Ma, Yang.,...&Wang, Hao.(2016).Thermo-controlled in situ phase transition of polymer-peptides on cell surfaces for high-performance proliferative inhibition.Acs applied materials & interfaces,8(27),17016-17022.
MLA	Qiao, Sheng-Lin,et al."Thermo-controlled in situ phase transition of polymer-peptides on cell surfaces for high-performance proliferative inhibition".Acs applied materials & interfaces 8.27(2016):17016-17022.

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