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	Transformable peptide nanocarriers for expeditious drug release and effective cancer therapy via cancer-associated fibroblast activation
	Ji, Tianjiao1; Zhao, Ying1; Ding, Yanping1; Wang, Jing1; Zhao, Ruifang1; Lang, Jiayan1; Qin, Hao1; Liu, Xiaoman2; Shi, Jian1; Tao, Ning2
刊名	Angewandte chemie-international edition
	2016-01-18
卷号	55期号:3页码:1050-1055
关键词	Cancer-associated fibroblasts Drug delivery Fibroblast activation protein-alpha Morphological transformation Peptide assembly
ISSN号	1433-7851
DOI	10.1002/anie.201506262
通讯作者	Zhao, yuliang(zhaoyl@nanoctr.cn)
英文摘要	A novel cleavable amphiphilic peptide (cap) was designed to be specifically responsive to fibroblast activation protein- (fap-), a protease specifically expressed on the surface of cancer-associated fibroblasts. the cap self-assembled into fiber-like nanostructures in solution, while the presence of hydrophobic chemotherapeutic drugs readily transformed the assemblies into drug-loaded spherical nanoparticles. the disassembly of these nanoparticles (cap-nps) upon fap- cleavage resulted in rapid and efficient release of the encapsulated drugs specifically at tumor sites. this transformers-like drug delivery strategy could allow them to disrupt the stromal barrier and enhance local drug accumulation. therapeutic results suggested that drug-loaded cap-nps hold promising tumor specificity and therapeutic efficacy for various solid tumor models, confirming its potential utility and versatility in antitumor therapy.
WOS关键词	STROMAL FIBROBLASTS ; SERINE-PROTEASE ; SURFACE-CHARGE ; NANOPARTICLES ; DELIVERY ; TUMORS ; PH ; HETEROGENEITY ; NANOMEDICINE ; SPECIFICITY
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000368070000036
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2176579
专题	高能物理研究所
通讯作者	Zhao, Yuliang
作者单位	1.Natl Ctr Nanosci & Technol NCNST, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Inst Biophys, CAS Key Lab Prot & Peptide Pharmaceut, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Ji, Tianjiao,Zhao, Ying,Ding, Yanping,et al. Transformable peptide nanocarriers for expeditious drug release and effective cancer therapy via cancer-associated fibroblast activation[J]. Angewandte chemie-international edition,2016,55(3):1050-1055.
APA	Ji, Tianjiao.,Zhao, Ying.,Ding, Yanping.,Wang, Jing.,Zhao, Ruifang.,...&Zhao, Yuliang.(2016).Transformable peptide nanocarriers for expeditious drug release and effective cancer therapy via cancer-associated fibroblast activation.Angewandte chemie-international edition,55(3),1050-1055.
MLA	Ji, Tianjiao,et al."Transformable peptide nanocarriers for expeditious drug release and effective cancer therapy via cancer-associated fibroblast activation".Angewandte chemie-international edition 55.3(2016):1050-1055.

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