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	Enhanced germicidal efficacy by co-delivery of validamycin and hexaconazole with methoxy poly(ethylene glycol)-poly(lactide-co-glycolide) nanoparticles
	Zhang, Jiakun1,2; Liu, Yajing2; Zhao, Caiyan1; Cao, Lidong2; Huang, Qiliang2; Wu, Yan1
刊名	Journal of nanoscience and nanotechnology
	2016
卷号	16期号:1页码:152-159
关键词	Co-delivery Nanoparticles Mpeg-plga Validamycin Hexaconazole
ISSN号	1533-4880
DOI	10.1166/jnn.2016.10674
通讯作者	Huang, qiliang() ; Wu, yan()
英文摘要	Co-delivery system has been proposed in pharmaceutical field aim to synergistic treatments. the combination formulation is also important in traditional pesticides formulations based on the low pest resistance risk and wide fungicidal spectrum. however, co-delivery nanoparticles (nps) tend to be more environmentally friendly for the sustained-release behaviour and none of toxic organic solvents or dusts. hence, we constructed co-delivery nps which could delivery two kinds of pesticides, which function was similar with pesticides combination formulation. the co-delivery nps of validamycin and hexaconazole were prepared with the amphiphilic copolymer methoxy poly(ethylene glycol)poly(lactide-co-glycolide) (mpeg-plga) used an improved double emulsion method. the chemical structure of mpeg-plga copolymer was confirmed using fourier transform infrared spectroscopy (ft-ir), and nuclear magnetic resonance spectroscopy (nmr). the co-delivery nps all exhibited good size distribution and held sustained-release property. germicidal efficacy of the co-delivery nps against rhizoctonia cerealis was also studied. the germicidal efficacy of co-delivery nps against rhizoctonia cerealis was better than that of traditional pesticides formulation. in addition, co-delivery nps showed a lasting impact against rhizoctonia cerealis.
WOS关键词	TARGETED DRUG-DELIVERY ; COPOLYMER NANOPARTICLES ; CONTROLLED-RELEASE ; PACLITAXEL ; DOXORUBICIN ; CELLS ; ACID ; HERBICIDES ; AVERMECTIN ; CHITOSAN
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
语种	英语
出版者	AMER SCIENTIFIC PUBLISHERS
WOS记录号	WOS:000369680400011
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2176563
专题	高能物理研究所
通讯作者	Huang, Qiliang; Wu, Yan
作者单位	1.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, 11 Beiyitiao, Beijing 100190, Peoples R China 2.CAAS, Inst Plant Protect, MOA, Key Lab Pesticide Chem & Applicat, 2 Yuanmingyuan West Rd, Beijing 100193, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Jiakun,Liu, Yajing,Zhao, Caiyan,et al. Enhanced germicidal efficacy by co-delivery of validamycin and hexaconazole with methoxy poly(ethylene glycol)-poly(lactide-co-glycolide) nanoparticles[J]. Journal of nanoscience and nanotechnology,2016,16(1):152-159.
APA	Zhang, Jiakun,Liu, Yajing,Zhao, Caiyan,Cao, Lidong,Huang, Qiliang,&Wu, Yan.(2016).Enhanced germicidal efficacy by co-delivery of validamycin and hexaconazole with methoxy poly(ethylene glycol)-poly(lactide-co-glycolide) nanoparticles.Journal of nanoscience and nanotechnology,16(1),152-159.
MLA	Zhang, Jiakun,et al."Enhanced germicidal efficacy by co-delivery of validamycin and hexaconazole with methoxy poly(ethylene glycol)-poly(lactide-co-glycolide) nanoparticles".Journal of nanoscience and nanotechnology 16.1(2016):152-159.

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