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	Subcellular behaviour evaluation of nanopharmaceuticals with aggregation-induced emission molecules
	Xue, Xiangdong1,2,3; Xu, Jing1,2; Wang, Paul C.4,5; Liang, Xing-Jie1,2
刊名	Journal of materials chemistry c
	2016
卷号	4期号:14页码:2719-2730
ISSN号	2050-7526
DOI	10.1039/c5tc03651h
通讯作者	Liang, xing-jie(liangxj@nanoctr.cn)
英文摘要	Nanopharmaceuticals possess a myriad of advantages for disease treatment, not only in delivering therapeutic agents, but also in deciphering their innate intracellular or subcellular behaviours, providing detailed diagnostic and prognostic information, quantifying treatment efficacy and designing better therapeutics. to evaluate the subcellular behaviour of nanopharmaceuticals, colourful fluorescence is the most potential technique, because it is capable of painting the subcellular detail in three dimensions with high resolution. furthermore, the fluorescence is switchable, and thus the subcellular details can be lightened specifically without the undesirable background. however, most nanopharmaceuticals lack a fluorescent report group, and its introduction requires extra steps. moreover, the introduced fluorescent groups can suffer from concentration quenching or aggregation-caused quenching (acq) when they are embedded in nanopharmaceuticals at a high concentration. the unique aggregation-induced emission (aie) effect provides a straightforward solution. the aromatic cores of aie molecules are always hydrophobic and do not undergo the acq effect even at high concentrations. hence, aie molecules can be directly introduced as building blocks to provide the driving force for the self-assembly of nanopharmaceuticals and can allow us to develop label-free, acq-free and luminescent nanopharmaceuticals that can simultaneously implement drug delivery and subcellular behaviour evaluation. this review presents different types of aie molecules-based nanopharmaceuticals and their biological properties and applications for imaging subcellular behaviours, including the drug releasing process, metabolism of nanopharmaceuticals, subcellular distributions of drug and carriers, and therapeutic effect. with detailed acquaintance of these subcellular behaviours, we anticipate that the research we discuss in this review can inspire other scientists to develop next generation nanopharmaceuticals that can be guided by fluorescence imaging and thus can realize concisely controllable drug delivery.
WOS关键词	INTRACELLULAR DRUG-DELIVERY ; IN-VIVO ; POLYMERIC MICELLES ; CANCER-THERAPY ; QUANTUM-DOT ; FLUORESCENT BIOPROBES ; GOLD NANOPARTICLES ; GENE DELIVERY ; EFFLUX ; NANOMATERIALS
WOS研究方向	Materials Science ; Physics
WOS类目	Materials Science, Multidisciplinary ; Physics, Applied
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000373611700007
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2176517
专题	高能物理研究所
通讯作者	Liang, Xing-Jie
作者单位	1.Chinese Acad Sci, Ctr Excellentce Nanosci, 11 Beiyitiao, Beijing 100190, Peoples R China 2.Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, 11 Beiyitiao, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Fu Jen Catholic Univ, Taipei 24205, Taiwan 5.Howard Univ, Dept Radiol, Lab Mol Imaging, Washington, DC 20060 USA
推荐引用方式 GB/T 7714	Xue, Xiangdong,Xu, Jing,Wang, Paul C.,et al. Subcellular behaviour evaluation of nanopharmaceuticals with aggregation-induced emission molecules[J]. Journal of materials chemistry c,2016,4(14):2719-2730.
APA	Xue, Xiangdong,Xu, Jing,Wang, Paul C.,&Liang, Xing-Jie.(2016).Subcellular behaviour evaluation of nanopharmaceuticals with aggregation-induced emission molecules.Journal of materials chemistry c,4(14),2719-2730.
MLA	Xue, Xiangdong,et al."Subcellular behaviour evaluation of nanopharmaceuticals with aggregation-induced emission molecules".Journal of materials chemistry c 4.14(2016):2719-2730.

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