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	Self-carried curcumin nanoparticles for in vitro and in vivo cancer therapy with real-time monitoring of drug release
	Zhang, Jinfeng1,2,3; Li, Shengliang4; An, Fei-Fei1; Liu, Juan4; Jin, Shubin4; Zhang, Jin-Chao5; Wang, Paul C.6; Zhang, Xiaohong1,7,8; Lee, Chun-Sing2,3; Liang, Xing-Jie4
刊名	Nanoscale
	2015
卷号	7期号:32页码:13503-13510
ISSN号	2040-3364
DOI	10.1039/c5nr03259h
通讯作者	Zhang, xiaohong(xiaohong_zhang@suda.edu.cn)
英文摘要	The use of different nanocarriers for delivering hydrophobic pharmaceutical agents to tumor sites has garnered major attention. despite the merits of these nanocarriers, further studies are needed to improve their drug loading capacities (which are typically <10%) and reduce their potential systemic toxicity. therefore, the development of alternative self-carried nanodrug delivery strategies without using inert carriers is highly desirable. in this study, we developed a self-carried curcumin (cur) nanodrug for highly effective cancer therapy in vitro and in vivo with real-time monitoring of drug release. with a biocompatible c18pmh-peg functionalization, the cur nanoparticles (nps) showed excellent dispersibility and outstanding stability in physiological environments with drug loading capacities >78 wt%. both confocal microscopy and flow cytometry confirmed the cellular fluorescence "off-on" activation and real-time monitoring of the cur molecule release. in vitro and in vivo experiments clearly show that the therapeutic efficacy of the pegylated cur nps is considerably better than that of free cur. this self-carried strategy with real-time monitoring of drug release may open a new way for simultaneous cancer therapy and monitoring.
WOS关键词	MESOPOROUS SILICA NANOPARTICLES ; RESONANCE ENERGY-TRANSFER ; PHOTODYNAMIC THERAPY ; THERANOSTIC PRODRUG ; CELLULAR UPTAKE ; PURE NANODRUGS ; DELIVERY ; NANOCARRIERS ; POLYMER ; FLUORESCENCE
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000359234100026
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2176412
专题	高能物理研究所
通讯作者	Zhang, Xiaohong
作者单位	1.Chinese Acad Sci, Tech Inst Phys & Chem, Nanoorgan Photoelect Lab, Beijing 100190, Peoples R China 2.City Univ Hong Kong, Ctr Super Diamond & Adv Films COSDAF, Hong Kong, Hong Kong, Peoples R China 3.City Univ Hong Kong, Dept Phys & Mat Sci, Hong Kong, Hong Kong, Peoples R China 4.Chinese Acad Sci, Natl Ctr Nanosci & Technol, Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 5.Hebei Univ, Chem Biol Key Lab Hebei Prov, Coll Chem & Environm Sci, Baoding, Peoples R China 6.Howard Univ, Dept Radiol, Mol Imaging Lab, Washington, DC 20059 USA 7.Soochow Univ, Funct Nano & Soft Mat Lab FUNSOM, Suzhou, Peoples R China 8.Soochow Univ, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Suzhou, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Jinfeng,Li, Shengliang,An, Fei-Fei,et al. Self-carried curcumin nanoparticles for in vitro and in vivo cancer therapy with real-time monitoring of drug release[J]. Nanoscale,2015,7(32):13503-13510.
APA	Zhang, Jinfeng.,Li, Shengliang.,An, Fei-Fei.,Liu, Juan.,Jin, Shubin.,...&Liang, Xing-Jie.(2015).Self-carried curcumin nanoparticles for in vitro and in vivo cancer therapy with real-time monitoring of drug release.Nanoscale,7(32),13503-13510.
MLA	Zhang, Jinfeng,et al."Self-carried curcumin nanoparticles for in vitro and in vivo cancer therapy with real-time monitoring of drug release".Nanoscale 7.32(2015):13503-13510.

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