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	Effect of iodine supplement on iodine status and 5 '-deiodinase activity in the brain of neonatal rats with iodine deficiency
	Liu, Nianqing; Zu, Aijun; Liang, Dongchun; Zhang, Zhiyong; Guo, Gang; Chai, Zhifang
刊名	Biological trace element research
	2006-12-01
卷号	114期号:1-3页码:207-215
关键词	Iodine deficiency Iodine excess Iodine level in thyroid 5 '-deiodinase Thyroid hormones
ISSN号	0163-4984
通讯作者	Liu, nianqing()
英文摘要	The weanling wistar rats of iodine deficiency were divided into three groups for supplementation of different levels of iodine (iodine-excessive [ie], iodine-adequate [ia], and iodine-deficient [id]), with a control group (c). the iodine content in the thyroid was determined by epithermal neutron activation analysis. the activities of 5'-deiodinase and 5-deiodinase in the brains were assayed by determining the conversion ratios of t4 to t3 and rt3, respectively. the thyroid hormones levels in serum were also tested. the results indicated that the id group had a goiter containing a small amount of iodine, but the ie group had a slightly swollen thyroid with rich iodine; the concentration of iodine per unit mass of thyroid was lower in group ie than in groups ia and c. the highest 5'-deiodinase and lowest 5-deiodinase activities in group id and the lowest 5'-deiodinase activity in group ie were found. the iodine deficiency or excess resulted in a compensated hypothyroid state. the results suggest that the iodine status and the deiodinases activities would become normal for the rats of iodine deficiency if adequate iodine is supplemented soon after birth. meanwhile, it is also critical to avoid excessive intake of iodine to reduce the risk for overcorrecting.
WOS关键词	IODOTHYRONINE DEIODINASE ; HYPOTHYROIDISM ; HYPERTHYROIDISM ; CONVERSION ; THYROXINE ; ENZYME
WOS研究方向	Biochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS类目	Biochemistry & Molecular Biology ; Endocrinology & Metabolism
语种	英语
出版者	HUMANA PRESS INC
WOS记录号	WOS:000243400700022
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2175839
专题	高能物理研究所
通讯作者	Liu, Nianqing
作者单位	1.Chinese Acad Sci, Inst High Energy Phys, Lab Nucl Analyt Tech, Beijing 100049, Peoples R China 2.Tianjin Inst Endocrinol, Tianjin 300070, Peoples R China
推荐引用方式 GB/T 7714	Liu, Nianqing,Zu, Aijun,Liang, Dongchun,et al. Effect of iodine supplement on iodine status and 5 '-deiodinase activity in the brain of neonatal rats with iodine deficiency[J]. Biological trace element research,2006,114(1-3):207-215.
APA	Liu, Nianqing,Zu, Aijun,Liang, Dongchun,Zhang, Zhiyong,Guo, Gang,&Chai, Zhifang.(2006).Effect of iodine supplement on iodine status and 5 '-deiodinase activity in the brain of neonatal rats with iodine deficiency.Biological trace element research,114(1-3),207-215.
MLA	Liu, Nianqing,et al."Effect of iodine supplement on iodine status and 5 '-deiodinase activity in the brain of neonatal rats with iodine deficiency".Biological trace element research 114.1-3(2006):207-215.

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