Mechanism of concentration addition toxicity: they are different for nonpolar narcotic chemicals, polar narcotic chemicals and reactive chemicals

CORC > 南海海洋研究所 > 中国科学院南海海洋研究所 > 热带海洋环境国家重点实验室(LTO)

	Mechanism of concentration addition toxicity: they are different for nonpolar narcotic chemicals, polar narcotic chemicals and reactive chemicals
	Lin, ZF ; Du, JW ; Yin, KD ; Wang, LS ; Yu, HX
刊名	CHEMOSPHERE
	2004
卷号	54 期号:11 页码:1691-1701
关键词	mechanism of concentration addition toxicity nonpolar narcotic chemical polar narcotic chemical reactive chemical
ISSN号	0045-6535
通讯作者	lzhifen@yahoo.com
中文摘要	According to the toxicity mechanism of the individual chemicals, the concentration addition toxicity mechanism is revealed for nonpolar-narcotic-chemical mixtures, polar-narcotic-chemical mixtures and reactive-chemical mixtures, respectively. For nonpolar-narcotic-chemical mixtures, the partitioning of individual chemicals from water to biophase was determined, and the result shows that their concentration additive effect results from no competitive partitioning among individual chemicals. For polar-narcotic-chemical mixtures, their toxicity are contributed by two factors (the total baseline toxicity and the hydrogen bond donor activity of individual chemicals), and it is the concentration additive effect for either of these two factors that leads to their concentration addition toxicity. In addition, the interactions between the reactive chemicals and the biological macromolecules are discussed thoroughly. The results suggest that the net effect of these interactions is zero, and it is this zero net effect that leads to the concentration addition toxicity mechanism for reactive-chemical mixtures. (C) 2003 Elsevier Ltd. All rights reserved.
学科主题	Environmental Sciences
收录类别	SCI
原文出处	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000189132000011
公开日期	2011-07-03
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/5663]
专题	南海海洋研究所_热带海洋环境国家重点实验室(LTO)
推荐引用方式 GB/T 7714	Lin, ZF,Du, JW,Yin, KD,et al. Mechanism of concentration addition toxicity: they are different for nonpolar narcotic chemicals, polar narcotic chemicals and reactive chemicals[J]. CHEMOSPHERE,2004,54(11):1691-1701.
APA	Lin, ZF,Du, JW,Yin, KD,Wang, LS,&Yu, HX.(2004).Mechanism of concentration addition toxicity: they are different for nonpolar narcotic chemicals, polar narcotic chemicals and reactive chemicals.CHEMOSPHERE,54(11),1691-1701.
MLA	Lin, ZF,et al."Mechanism of concentration addition toxicity: they are different for nonpolar narcotic chemicals, polar narcotic chemicals and reactive chemicals".CHEMOSPHERE 54.11(2004):1691-1701.