Electrochromatographic evaluation of a silica monolith capillary column for separation of basic pharmaceuticals

	Electrochromatographic evaluation of a silica monolith capillary column for separation of basic pharmaceuticals
	Xie, CH ; Hu, JW ; Xiao, H ; Su, XY ; Dong, J ; Tian, RJ ; He, ZK ; Zou, HF
刊名	electrophoresis
	2005-02-01
卷号	26 期号:4-5 页码:790-797
关键词	basic pharmaceutical electrochromatography retention mechanism silica monolith
ISSN号	0173-0835
通讯作者	邹汉法
产权排序	1;1
英文摘要	a silica-based monolithic capillary column was prepared via a sol-gel process. the continuous skeleton and large through-pore structure were characterized by scanning electron microscopy (sem). the native silica monolith has been successfully employed in the electrochromatographic separation of beta-blockers and alkaloids extracted from traditional chinese medicines (tcms). column efficiencies greater than 250000 plates/m for capillary electrochromatography (cec) separation of basic compounds were obtained. it was observed that retention of basic pharmaceuticals on the silica monolith was mainly contributed by a cation-exchange mechanism. other retention mechanisms including reversed-phase and normal-phase mechanisms and electrophoresis of basic compounds also played a role in separation. a comparison of the differences between cec and capillary zone electrophoresis (cze) separation was also discussed.
WOS标题词	science & technology ; life sciences & biomedicine ; physical sciences
类目[WOS]	biochemical research methods ; chemistry, analytical
研究领域[WOS]	biochemistry & molecular biology ; chemistry
关键词[WOS]	performance liquid-chromatography ; aqueous methanol eluent ; reversed-phase ; stationary-phase ; drugs ; acid ; gel ; enantioseparation
收录类别	SCI
原文出处	true
语种	英语
WOS记录号	WOS:000227425400007
公开日期	2010-11-30
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/92743]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116011, Peoples R China 2.Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China
推荐引用方式 GB/T 7714	Xie, CH,Hu, JW,Xiao, H,et al. Electrochromatographic evaluation of a silica monolith capillary column for separation of basic pharmaceuticals[J]. electrophoresis,2005,26(4-5):790-797.
APA	Xie, CH.,Hu, JW.,Xiao, H.,Su, XY.,Dong, J.,...&Zou, HF.(2005).Electrochromatographic evaluation of a silica monolith capillary column for separation of basic pharmaceuticals.electrophoresis,26(4-5),790-797.
MLA	Xie, CH,et al."Electrochromatographic evaluation of a silica monolith capillary column for separation of basic pharmaceuticals".electrophoresis 26.4-5(2005):790-797.