Effects of glucose administration on glucose and lipid metabolism in two strains of gibel carp (Carassius gibelio)

doi:10.1016/j.ygcen.2018.05.023

CORC > 武汉植物园 > 中国科学院武汉植物园

	Effects of glucose administration on glucose and lipid metabolism in two strains of gibel carp (Carassius gibelio)
	Xie, Shouqi; Liu, Haokun; Han, Dong; Zhu, Xiaoming; Yang, Yunxia; Jin, Junyan
刊名	GENERAL AND COMPARATIVE ENDOCRINOLOGY
	2018-10-01
卷号	267 页码:18-28
关键词	Glucose injection Liver Muscle Genotype A strain DT strain
ISSN号	0016-6480
DOI	10.1016/j.ygcen.2018.05.023
英文摘要	We compared the glucose clearance ability of gibel carp CAS III (A strain) with gibel carp Dongting (DT strain). A previous study suggested that these two strains responded to insulin differently. As insulin plays an important role in glucose utilization, we hypothesized that the ability to eliminate excess glucose after a glucose load would differ between A strain and DT strain. To test this hypothesis, fasted specimens of both strains of gibel carp were injected with glucose. As expected, glucose induced hyperglycemia in both A strain and DT strain. In both strains, mRNA levels of the glycolytic enzyme 6-phosphofructokinase (6PFK) increased in the white skeletal muscle 8 h post-injection, while expression levels of glucose-6-phosphatase (G6Pase), fructose 1,6-bisphosphatase (FBPase), and phosphoenolpyruvate carboxykinase (PEPCK) decreased in the liver 8 h post-injection. In the DT strain, both GLUT4 expression and muscular glycolytic processes increased, as reflected by elevated hexokinase 2 (HK2) and pyruvate kinase (PK) mRNA expression levels. The DT strain also returned to basal glycemia more quickly than the A strain (within 6 h versus more than 12 h). The glycogen concentration in the liver of the DT strain was higher than that of the A strain, indicating that the DT strain was better able to store glucose as glycogen than the A strain. Overall, the DT strain was better able to clear excess blood glucose after the glucose tolerance test than the A strain.
资助项目	National Natural Science Foundation of China[31101908] ; National Natural Science Foundation of China[31672670] ; National Natural Science Foundation of China[31602174] ; China Agriculture Research System[CARS-45-09] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA08010405] ; Knowledge Innovation Program of the Chinese Academy of Sciences
WOS研究方向	Endocrinology & Metabolism
语种	英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号	WOS:000444366400003
内容类型	期刊论文
源URL	[http://202.127.146.157/handle/2RYDP1HH/5800]
专题	中国科学院武汉植物园
通讯作者	Xie, Shouqi
作者单位	Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Hubei, Peoples R China
推荐引用方式 GB/T 7714	Xie, Shouqi,Liu, Haokun,Han, Dong,et al. Effects of glucose administration on glucose and lipid metabolism in two strains of gibel carp (Carassius gibelio)[J]. GENERAL AND COMPARATIVE ENDOCRINOLOGY,2018,267:18-28.
APA	Xie, Shouqi,Liu, Haokun,Han, Dong,Zhu, Xiaoming,Yang, Yunxia,&Jin, Junyan.(2018).Effects of glucose administration on glucose and lipid metabolism in two strains of gibel carp (Carassius gibelio).GENERAL AND COMPARATIVE ENDOCRINOLOGY,267,18-28.
MLA	Xie, Shouqi,et al."Effects of glucose administration on glucose and lipid metabolism in two strains of gibel carp (Carassius gibelio)".GENERAL AND COMPARATIVE ENDOCRINOLOGY 267(2018):18-28.