Engineering of Fc Fragments with Optimized Physicochemical Properties Implying Improvement of Clinical Potentials for Fc-Based Therapeutics

doi:10.3389/fimmu.2017.01860

CORC > 武汉植物园 > 中国科学院武汉植物园

	Engineering of Fc Fragments with Optimized Physicochemical Properties Implying Improvement of Clinical Potentials for Fc-Based Therapeutics
	Yang, Chunpeng 1,2; Gao, Xinyu 1,2; Gong, Rui 1
刊名	FRONTIERS IN IMMUNOLOGY
	2018-01-08
卷号	8 页码:14
关键词	monoclonal antibody Fc-fusion protein Fc-based therapeutics optimization physicochemical property stability aggregation
ISSN号	1664-3224
DOI	10.3389/fimmu.2017.01860
英文摘要	Therapeutic monoclonal antibodies and Fc-fusion proteins are successfully used in treatment of various diseases mainly including cancer, immune disease, and viral infection, which belong to the Fc-based therapeutics. In recent years, engineered Fc-derived antibody domains have also shown potential for Fc-based therapeutics. To increase the druggability of Fc-based therapeutic candidates, many efforts have been made in optimizing physicochemical properties and functions mediated by Fc fragment. The desired result is that we can simultaneously obtain Fc variants with increased physicochemical properties in vitro and capacity of mediating appropriate functions in vivo. However, changes of physicochemical properties of Fc may result in alternation of Fc-mediated functions and vice versa, which leads to undesired outcomes for further development of Fc-based therapeutics. Therefore, whether modified Fc fragments are suitable for achievement of expected clinical results or not needs to be seriously considered. Now, this question comes to be noticed and should be figured out to make better translation from the results of laboratory into clinical applications. In this review, we summarize different strategies on engineering physicochemical properties of Fc, and preliminarily elucidate the relationships between modified Fc in vitro and the subsequent therapeutic influence in vivo.
资助项目	Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12020346] ; Key Program of Chinese Academy of Sciences[ZDRW-ZS-2016-4] ; National Key Research and Development Program of China[2016YFC1202902] ; One-Three-Five Strategic Programs of Wuhan Institute of Virology, Chinese Academy of Sciences[Y605221SA1] ; Wuhan Key Laboratory on Emerging Infectious Diseases and Biosafety
WOS研究方向	Immunology
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000419445800001
内容类型	期刊论文
源URL	[http://202.127.146.157/handle/2RYDP1HH/4499]
专题	中国科学院武汉植物园
通讯作者	Gong, Rui
作者单位	1.Chinese Acad Sci, Wuhan Inst Virol, CAS Key Lab Special Pathogens & Biosafety, Wuhan, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Yang, Chunpeng,Gao, Xinyu,Gong, Rui. Engineering of Fc Fragments with Optimized Physicochemical Properties Implying Improvement of Clinical Potentials for Fc-Based Therapeutics[J]. FRONTIERS IN IMMUNOLOGY,2018,8:14.
APA	Yang, Chunpeng,Gao, Xinyu,&Gong, Rui.(2018).Engineering of Fc Fragments with Optimized Physicochemical Properties Implying Improvement of Clinical Potentials for Fc-Based Therapeutics.FRONTIERS IN IMMUNOLOGY,8,14.
MLA	Yang, Chunpeng,et al."Engineering of Fc Fragments with Optimized Physicochemical Properties Implying Improvement of Clinical Potentials for Fc-Based Therapeutics".FRONTIERS IN IMMUNOLOGY 8(2018):14.