Design, Synthesis of N-phenethyl Cinnamide Derivatives and Their Biological Activities for the Treatment of Alzheimer’s Disease: Antioxidant, Beta-amyloid Disaggregating and Rescue Effects on Memory l

doi:10.3390/molecules23102663

CORC > 兰州化学物理研究所 > 中国科学院兰州化学物理研究所 > 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室

	Design, Synthesis of N-phenethyl Cinnamide Derivatives and Their Biological Activities for the Treatment of Alzheimer’s Disease: Antioxidant, Beta-amyloid Disaggregating and Rescue Effects on Memory l
	Tian Chai 1; Xiao-Bo Zhao 2; Wei-Feng Wang 2; Yin Qiang 1; Xiao-Yun Zhang 1; Jun-Li Yang2
刊名	Molecules
	2018
卷号	23 期号:10 页码:2663
关键词	Alzheimer’s Disease Gx-50 Dpph Assay Tht Assay Transgenic Drosophila Model Assay
DOI	10.3390/molecules23102663
英文摘要	Gx-50 is a bioactive compound for the treatment of Alzheimer’s disease (AD) found in Sichuan pepper (Zanthoxylum bungeanum). In order to find a stronger anti-AD lead compound, 20 gx-50 (1–20) analogs have been designed and synthesized, and their molecular structures were determined based on nuclear magnetic resonance (NMR) and mass spectrometry (MS) analysis, as well as comparison with literature data. Compounds 1–20 were evaluated for their anti-AD potential by using DPPH radical scavenging assay for considering their anti-oxidant activity, thioflavin T (ThT) fluorescence assay for considering the inhibitory or disaggregate potency of Aβ, and transgenic Drosophila model assay for evaluating their rescue effect on memory loss. Finally, compound 13 was determined as a promising anti-AD candidate.
语种	英语
内容类型	期刊论文
源URL	[http://210.77.64.217/handle/362003/24247]
专题	兰州化学物理研究所_中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室
通讯作者	Jun-Li Yang
作者单位	1.Lanzhou University 2.Lanzhou Institute of Chemical Physics (LICP), Chinese Academy of Sciences (CAS)
推荐引用方式 GB/T 7714	Tian Chai,Xiao-Bo Zhao,Wei-Feng Wang,et al. Design, Synthesis of N-phenethyl Cinnamide Derivatives and Their Biological Activities for the Treatment of Alzheimer’s Disease: Antioxidant, Beta-amyloid Disaggregating and Rescue Effects on Memory l[J]. Molecules,2018,23(10):2663.
APA	Tian Chai,Xiao-Bo Zhao,Wei-Feng Wang,Yin Qiang,Xiao-Yun Zhang,&Jun-Li Yang.(2018).Design, Synthesis of N-phenethyl Cinnamide Derivatives and Their Biological Activities for the Treatment of Alzheimer’s Disease: Antioxidant, Beta-amyloid Disaggregating and Rescue Effects on Memory l.Molecules,23(10),2663.
MLA	Tian Chai,et al."Design, Synthesis of N-phenethyl Cinnamide Derivatives and Their Biological Activities for the Treatment of Alzheimer’s Disease: Antioxidant, Beta-amyloid Disaggregating and Rescue Effects on Memory l".Molecules 23.10(2018):2663.