Curing the Toxicity of Multi-Walled Carbon Nanotubes through Native Small-molecule Drugs | |
Qi, Wei1; Tian, Longlong2; An, Wenzhen2; Wu, Qiang2; Liu, Jianli3; Jiang, Can5; Yang, Jun6; Tang, Bing6; Zhang, Yafeng6; Xie, Kangjun1 | |
刊名 | Scientific Reports |
2017 | |
卷号 | 7页码:2815(1-14) |
ISSN号 | 2045-2322 |
DOI | 10.1038/s41598-017-02770-5 |
英文摘要 | With the development and application of nanotechnology, large amounts of nanoparticles will be potentially released to the environment and possibly cause many severe health problems. Although the toxicity of nanoparticles has been investigated, prevention and treatment of damages caused by nanoparticles have been rarely studied. Therefore, isotope tracing and improved CT imaging techniques were used to investigate the biodistribution influence between oMWCNTs(oxidized multi-walled carbon nanotubes) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC)/or simvastatin (TD) in vivo. What’s more, biochemical indices in plasma and tissue histology were measured to further study therapeutic effects on the damages of oMWCNTs in mice. Isotope tracing and improved CT imaging results showed that low dosages of DOPC and TD didn’t affect the distribution of oMWCNTs in mice; conversely, the distribution and metabolism of DOPC and TD were influenced by oMWCNTs. Moreover, DOPC and/or TD improved the biocompatibility of oMWCNTs in erythrocyte suspension in vitro. Biochemical index and histopathological results indicated that DOPC and TD didn’t prevent injuries caused by oMWCNTs effectively. But TD showed a good therapeutic effect for damages. This study is the first to investigate prevention and treatment effects of drugs on damages caused by oMWCNTs and provides new insights and breakthroughs for management of nanoparticles on health hazards. |
学科主题 | 分析化学与药物化学 |
资助项目 | 药物分离材料研究组 |
语种 | 英语 |
WOS记录号 | WOS:000425906100004 |
资助机构 | the National Natural Science Foundation of China (Nos J21327801;11305068) |
内容类型 | 期刊论文 |
源URL | [http://ir.licp.ac.cn/handle/362003/23721] |
专题 | 兰州化学物理研究所_中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
通讯作者 | Qi, Wei; Li Z(李湛); Wu WS(吴王锁) |
作者单位 | 1.Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, Wuhan 430074, Hubei, Peoples R China 2.Lanzhou Univ, Lanzhou 730000, Gansu, Peoples R China 3.Lanzhou Univ, Hosp 2, Lanzhou 730000, Gansu, Peoples R China 4.Chinese Acad Sci, Lanzhou Inst Chem Phys, Lanzhou 730000, Gansu, Peoples R China 5.Hubei Univ Sci & Technol, Nonpower Nucl Technol Res & Dev Ctr, Xianning City 437000, Hubei, Peoples R China 6.Huazhong Univ Sci & Technol, Inst Appl & Elect Engn, Wuhan 430074, Hubei, Peoples R China 7.Xinjiang Med Univ, Coll Pharm, Urumqi 830011, Xinjiang Provin, Peoples R China |
推荐引用方式 GB/T 7714 | Qi, Wei,Tian, Longlong,An, Wenzhen,et al. Curing the Toxicity of Multi-Walled Carbon Nanotubes through Native Small-molecule Drugs[J]. Scientific Reports,2017,7:2815(1-14). |
APA | Qi, Wei.,Tian, Longlong.,An, Wenzhen.,Wu, Qiang.,Liu, Jianli.,...&吴王锁.(2017).Curing the Toxicity of Multi-Walled Carbon Nanotubes through Native Small-molecule Drugs.Scientific Reports,7,2815(1-14). |
MLA | Qi, Wei,et al."Curing the Toxicity of Multi-Walled Carbon Nanotubes through Native Small-molecule Drugs".Scientific Reports 7(2017):2815(1-14). |
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