Two-Dimensional Ultrathin MXene Ceramic Nanosheets for Photothermal Conversion

doi:10.1021/acs.nanolett.6b04339

	Two-Dimensional Ultrathin MXene Ceramic Nanosheets for Photothermal Conversion
	Lin, Han 1,2; Wang, Xingang 1; Yu, Luodan 1,2; Chen, Yu 1; Shi, Jianlin 1
刊名	Nano Letters
	2017
卷号	17 期号:1 页码:384-391
ISSN号	15306984
DOI	10.1021/acs.nanolett.6b04339
英文摘要	Ceramic biomaterials have been investigated for several decades, but their potential biomedical applications in cancer therapy have been paid much less attentions, mainly due to their lack of related material functionality for combating the cancer. In this work, we report, for the first time, that MAX ceramic biomaterials exhibit the unique functionality for the photothermal ablation of cancer upon being exfoliated into ultrathin nanosheets within atomic thickness (MXene). As a paradigm, biocompatible Ti3C2nanosheets (MXenes) were successfully synthesized based on a two-step exfoliation strategy of MAX phase Ti3AlC2by the combined HF etching and TPAOH intercalation. Especially, the high photothermalconversion efficiency and in vitro/in vivo photothermal ablation of tumor of Ti3C2nanosheets (MXenes) were revealed and demonstrated, not only in the intravenous administration of soybean phospholipid modified Ti3C2nanosheets but also in the localized intratumoral implantation of a phase-changeable PLGA/Ti3C2organic-inorganic hybrid. This work promises the great potential of Ti3C2nanosheets (MXenes) as a novel ceramic photothermal agent used for cancer therapy and may arouse much interest in exploring MXene-based ceramic biomaterials to benefit the biomedical applications. © 2016 American Chemical Society.
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/25638]
专题	中国科学院上海硅酸盐研究所
作者单位	1.State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China; 2.University of Chinese Academy of Sciences, Beijing; 100049, China
推荐引用方式 GB/T 7714	Lin, Han,Wang, Xingang,Yu, Luodan,et al. Two-Dimensional Ultrathin MXene Ceramic Nanosheets for Photothermal Conversion[J]. Nano Letters,2017,17(1):384-391.
APA	Lin, Han,Wang, Xingang,Yu, Luodan,Chen, Yu,&Shi, Jianlin.(2017).Two-Dimensional Ultrathin MXene Ceramic Nanosheets for Photothermal Conversion.Nano Letters,17(1),384-391.
MLA	Lin, Han,et al."Two-Dimensional Ultrathin MXene Ceramic Nanosheets for Photothermal Conversion".Nano Letters 17.1(2017):384-391.