Targeting Upconversion Nanoprobes for Magnetic Resonance Imaging of Early Colon Cancer

doi:10.1002/ppsc.201600393

	Targeting Upconversion Nanoprobes for Magnetic Resonance Imaging of Early Colon Cancer
	Jin, Yingying 1; Ni, Dalong 2; Zhang, Jiawen 1; Han, Fang 1; Wang, Jing 1; Gao, Lu 1; Zhang, Hua 1; Liu, Yanyan 2; Cui, Zhaowen 2; Yao, Zhenwei 1
刊名	Particle and Particle Systems Characterization
	2017
卷号	34 期号:3
ISSN号	09340866
DOI	10.1002/ppsc.201600393
英文摘要	Colon cancer (CC) is one of the most common intestinal malignancies and is difficult to detect in its early stage by magnetic resonance imaging (MRI) with currently used contrast agents (CAs). The development of targeted CAs contributes to the early diagnosis of CC and thereby enables early intervention and timely therapy. Considering the outstanding performance of upconversion nanoprobes (UCNPs) in high-performance MR and fluorescence imaging, a new type of nanoprobes with considerably enhanced imaging performance is developed herein. Carcinoembryonic antigen (CEA) antibody is conjugated onto the surface of UCNPs to achieve the targeted imaging of early CC tumors, which overexpress CEA. Both toxicity tests and histological/hematological examinations demonstrate the excellent biocompatibility of these CC-targeting nanoprobes, which possess great potential for clinical application in the early diagnosis of CC. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/25738]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Department of Radiology, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai; 200040, China; 2.State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai; 200050, China; 3.Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai; 200062, China
推荐引用方式 GB/T 7714	Jin, Yingying,Ni, Dalong,Zhang, Jiawen,et al. Targeting Upconversion Nanoprobes for Magnetic Resonance Imaging of Early Colon Cancer[J]. Particle and Particle Systems Characterization,2017,34(3).
APA	Jin, Yingying.,Ni, Dalong.,Zhang, Jiawen.,Han, Fang.,Wang, Jing.,...&Bu, Wenbo.(2017).Targeting Upconversion Nanoprobes for Magnetic Resonance Imaging of Early Colon Cancer.Particle and Particle Systems Characterization,34(3).
MLA	Jin, Yingying,et al."Targeting Upconversion Nanoprobes for Magnetic Resonance Imaging of Early Colon Cancer".Particle and Particle Systems Characterization 34.3(2017).